{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:40:15Z","timestamp":1730824815962,"version":"3.28.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Es existieren einige Studien und Einzelfallberichte, welche eine Verbindung\n                    zwischen einer Hypothyreose und Reproduktionsst\u00f6rungen bei der H\u00fcndin und einer\n                    erh\u00f6hten neonatalen Mortalit\u00e4t und Morbidit\u00e4t bei Welpen postulieren. Andere\n                    Arbeiten wiederum k\u00f6nnen einen Zusammenhang im Hinblick auf eine Verbindung\n                    zwischen einer Hypothyreose und Reproduktionsst\u00f6rungen bei der H\u00fcndin nicht\n                    nachweisen. In dieser Arbeit soll die entsprechende Literatur auf ihre Evidenz\n                    \u00fcberpr\u00fcft werden. Anhand einer Literaturauswertung wird der Zusammenhang\n                    zwischen Hypothyreose und Reproduktionsst\u00f6rungen der H\u00fcndin, Welpensterblichkeit\n                    und neonataler Morbidit\u00e4t, analysiert. Dazu wurde die zur Verf\u00fcgung stehende\n                    deutsche und internationale \u201eenglischsprachige\u201c Literatur von 1986 bis Januar\n                    2023 analysiert. Es zeigt sich, dass nur wenig Literatur hohe wissenschaftliche\n                    Evidenz aufweist, da es sich zumeist um Fallberichte und Expertenmeinungen\n                    handelt. In einigen Einzelfallberichten konnte zwar ein Zusammenhang zwischen\n                    Zyklusunregelm\u00e4\u00dfigkeiten, Galaktorrh\u00f6 und Infertilit\u00e4t und dem Vorliegen einer\n                    Hypothyreose gesehen werden; in experimentellen Untersuchungen und nach Meinung\n                    anderer Autoren ist der Zusammenhang zwischen Hypothyreose und\n                    Reproduktionsst\u00f6rungen jedoch nicht vorhanden. Auch ein negativer Einfluss der\n                    Hypothyreose auf den Geburtsablauf konnte nicht eindeutig belegt werden. In\n                    einer experimentellen Studie waren zwar die Dauer und die Intensit\u00e4t der\n                    Uteruskontraktionen bei Tieren mit Hypothyreose l\u00e4nger und schw\u00e4cher, jedoch war\n                    das Intervall zwischen der Geburt von Welpen nicht beeintr\u00e4chtigt. Lediglich im\n                    Bereich der neonatalen Mortalit\u00e4t sowie Morbidit\u00e4t lie\u00df sich ein Zusammenhang\n                    mit der Hypothyreose des Muttertieres aufzeigen. Die Welpen betroffener\n                    H\u00fcndinnen zeigten ein geringeres Geburtsgewicht und waren lebensschw\u00e4cher als\n                    Welpen von euthyreoten H\u00fcndinnen. Die Bedeutung einer Schilddr\u00fcsenunterfunktion\n                    f\u00fcr die Fruchtbarkeit bei der H\u00fcndin ist in der Literatur noch nicht belegt.\n                    Diese Endokrinopathie scheint aber Einfluss auf die neonatale Vitalit\u00e4t zu\n                    haben.<\/jats:p>","DOI":"10.1055\/a-2364-2544","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T22:49:07Z","timestamp":1724366947000},"page":"220-231","source":"Crossref","is-referenced-by-count":0,"title":["Einfluss der Hypothyreose auf die Fruchtbarkeit bei der H\u00fcndin und\n                    die neonatale Mortalit\u00e4t und Morbidit\u00e4t \u2013 eine\n                    Literatur\u00fcbersicht"],"prefix":"10.1055","volume":"52","author":[{"given":"Rebecca","family":"Egger","sequence":"additional","affiliation":[{"name":"Tierklinik Dinkelsb\u00fchl GmbH, Dinkelsb\u00fchl"},{"name":"Tierklinik f\u00fcr Reproduktionsmedizin und Neugeborenenkunde,\n                    Justus-Liebig-Universit\u00e4t, Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Conze","sequence":"additional","affiliation":[{"name":"Tierklinik Dinkelsb\u00fchl GmbH, Dinkelsb\u00fchl"},{"name":"ReproVet Consulting, Dinkelsb\u00fchl"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Wehrend","sequence":"additional","affiliation":[{"name":"Tierklinik f\u00fcr Reproduktionsmedizin und Neugeborenenkunde,\n                    Justus-Liebig-Universit\u00e4t, Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1053\/svms.2002.34643","article-title":"Thyroid Issues in Reproduction","volume":"17","author":"C A Johnson","year":"2002","journal-title":"Clin Tech Small Anim Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.theriogenology.2007.04.026","article-title":"Effect of short-term hypothyroidism on reproduction in the bitch","volume":"68","author":"D L Panciera","year":"2007","journal-title":"Theriogenol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1939-1676.2011.00872.x","article-title":"Reproductive Effects of Prolonged Experimentally Induced Hypothyroidism in\n                    Bitches","volume":"26","author":"D L Panciera","year":"2012","journal-title":"J Vet Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cvsm.2007.05.002","article-title":"Etiopathologic findings of canine hypothyroidism","volume":"37","author":"P A Graham","year":"2007","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0028-1105894","article-title":"Schilddr\u00fcsenerkrankungen in der Schwangerschaft","volume":"134","author":"R G\u00e4rtner","year":"2009","journal-title":"DMW"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/09513590701464092","article-title":"Iodine and thyroid hormones during pregnancy and postpartum","volume":"23","author":"F R P\u00e9rez-L\u00f3pez","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1055\/s-2006-924518","article-title":"Schilddr\u00fcse und Schwangerschaft","volume":"67","author":"K J B\u00fchling","year":"2007","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1097\/01.AOG.0000244103.91597.c5","article-title":"Thyroid disease in pregnancy","volume":"108","author":"B M Casey","year":"2006","journal-title":"Am J Obst and Gynecol"},{"key":"ref11","first-page":"45","article-title":"Schilddr\u00fcse bei unerf\u00fclltem Kinderwunsch, in Schwangerschaft und Stillzeit","volume":"3","author":"M Ludwig","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1093\/clinchem\/45.12.2250","article-title":"Thyroid function during pregnancy","volume":"45","author":"C R Fantz","year":"1999","journal-title":"Clin Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1056\/NEJM199410203311608","article-title":"Maternal and fetal thyroid function","volume":"331","author":"G N Burrow","year":"1994","journal-title":"New Engl J Med"},{"key":"ref14","first-page":"269","volume-title":"Thyroid disease and pregnancy. 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