{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:29:34Z","timestamp":1730870974409,"version":"3.28.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ein 1,5-j\u00e4hriger, m\u00e4nnlich intakter Deutscher Jagdterrier wurde erstmalig 2018\n                    mit H\u00e4maturie vorstellig. In einer abdominalen Ultraschalluntersuchung wurden\n                    multiple hyperechogene Strukturen in der Harnblase festgestellt. Eine\n                    Urinuntersuchung wies auf eine hochgradige Ammoniumurat- oder\n                    Xanthin-Kristallurie hin. Erst nach einer Zystotomie und einer Harnsteinanalyse\n                    konnte 2019 eine Ammoniumurat-Urolithiasis diagnostiziert werden. Der Patient\n                    wurde homozygot f\u00fcr die SLC2A9:p.C188F Variante, welche in eine\n                    hochgradige Hyperurik\u00e4mie und Hyperurikosurie resultiert, getestet. Diese\n                    Kasuistik berichtet \u00fcber den ersten publizierten Fall eines Deutschen\n                    Jagdterriers, bei dem die SLC2A9:p.C188F Variante nachgewiesen wurde. Die\n                    Leserschaft soll daf\u00fcr sensibilisiert werden, dass dieser Gendefekt auch in\n                    anderen Rassen als Dalmatinern auftreten kann.<\/jats:p>","DOI":"10.1055\/a-2364-2603","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T22:49:07Z","timestamp":1724366947000},"page":"232-237","source":"Crossref","is-referenced-by-count":0,"title":["Erstmaliger Nachweis des SLC2A9:p.C188F Gendefekts bei einem\n                    Deutschen Jagdterrier mit Ammoniumurat-Urolithiasis"],"prefix":"10.1055","volume":"52","author":[{"given":"Christin","family":"Emming","sequence":"additional","affiliation":[{"name":"Stiftung Tier\u00e4rztliche Hochschule Hannover \u2013 Klinik f\u00fcr Kleintiere,\n                    Hannover, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hadjiafxentis","sequence":"additional","affiliation":[{"name":"Kleintierklinik Frank, Freiburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Liesegang","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierern\u00e4hrung und Di\u00e4tetik, Vetsuisse Fakult\u00e4t, UZH,\n                    Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Gampe","sequence":"additional","affiliation":[{"name":"AniCura Ludwigsburg O\u00dfweil GmbH, Ludwigsburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/ndt\/gfs574","article-title":"Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal\n                    reabsorption of urate","volume":"28","author":"T Nakanishi","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"J Maiuolo","year":"2016","journal-title":"Int J Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/s41585-020-00387-4","article-title":"Animal models of naturally occurring stone disease","volume":"17","author":"A Alford","year":"2020","journal-title":"Nat Rev Urol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1111\/jvim.14559","article-title":"ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of\n                    Uroliths in Dogs and Cats","volume":"30","author":"J P Lulich","year":"2016","journal-title":"J Vet Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","article-title":"The molecular physiology of uric acid homeostasis","volume":"77","author":"A K Mandal","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"ref6","first-page":"468","article-title":"Urate Urolithiasis","author":"J McCue","year":"2009","journal-title":"Compendium: Continuing Education for Veterinarians"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11926-016-0587-7","article-title":"Urate Handling in the Human Body","volume":"18","author":"D Hyndman","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.semnephrol.2020.12.003","article-title":"Uric Acid and Urate in Urolithiasis: The Innocent Bystander, Instigator, and\n                    Perpetrator","volume":"40","author":"E Adomako","year":"2020","journal-title":"Semin Nephrol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1055\/a-1334-0733","article-title":"Occurrence of uroliths \u2013 age-, breed-, and gender-specific differences in dogs\n                    from Germany","volume":"49","author":"D Breu","year":"2021","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0034-1381912","article-title":"Urate bei Erkrankungen der Harnblase","volume":"24 n\u00b01","author":"C Villaverde","year":"2014","journal-title":"Veterinary Focus"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.cvsm.2015.03.001","article-title":"Urolithiasis","volume":"45","author":"J W Bartges","year":"2015","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/s0195-5616(99)50010-7","article-title":"Canine urate urolithiasis. 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Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2364-2603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:06:07Z","timestamp":1730822767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2364-2603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":26,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,8,22]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2364-2603","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}