{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T05:36:46Z","timestamp":1736573806678,"version":"3.32.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital adrenal hyperplasia (CAH) manifests as an autosomal recessive disorder\n                    characterized by defects in the enzymes responsible for steroid synthesis. This\n                    work aims to perform metabolic profiling of patients with CAH, screen key\n                    differential metabolites compared to the control group, and discover the\n                    associated metabolic pathways implicated in CAH. Serum samples obtained from 32\n                    pediatric male patients with CAH and 31 healthy control group candidates were\n                    subjected to analysis using non-targeted metabolomics strategy using ultra\n                    performance liquid chromatography-tandem mass spectrometry (UPLC-MS\/MS). A total\n                    of 278 differential metabolites were identified and annotated in KEGG. Operating\n                    characteristic curves (ROC) measurement exhibited 9 metabolites exhibiting high\n                    efficacy in differential diagnosis, as evidenced by an area under ROC curve\n                    (AUC) exceeding 0.85. Pathway analysis uncovered notable disruptions in steroid\n                    hormone biosynthesis (p &lt;0.0001), purine metabolism and irregularities in\n                    lipid metabolism and amino acid metabolism, including tyrosine and alanine, in\n                    CAH patients. These findings demonstrate that metabolic pathways of purine,\n                    amino acid and lipid metabolism, apart from steroid hormone biosynthesis, may be\n                    disrupted and associated with CAH. This study helps provide insight into the\n                    metabolic profile of CAH patients and offers a new perspective for monitoring\n                    and administering follow-up care to CAH patients.<\/jats:p>","DOI":"10.1055\/a-2365-7521","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T23:03:55Z","timestamp":1723503835000},"page":"39-46","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Profiling Analysis of Congenital Adrenal Hyperplasia via an\n                    Untargeted Metabolomics Strategy"],"prefix":"10.1055","volume":"57","author":[{"given":"Fangling","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongxin","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College,\n                    Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College,\n                    Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuying","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Chi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of the State\n                    Ethnic Affairs Commission, School of Chemistry and Materials Science,\n                    South-Central Minzu University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/S0140-6736(17)31431-9","article-title":"Congenital adrenal 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