{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:33:07Z","timestamp":1790879587382,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Hydrocephalus is a neurological disease with higher prevalence in the pediatric population, often managed by placing a shunt. This hollow tube drains excess cerebrospinal fluid from the brain to other body parts, resulting in several complications, including neurological and psychometric manifestations and a compromised quality of life (QoL). This study aimed to evaluate QoL in patients with hydrocephalus shunt placement within the pediatric population.<\/jats:p><jats:p>\n          Methods\u2003This prospective observational study was conducted in two major Pakistani tertiary care hospitals. A total of 100 subjects were enrolled, of which 52 were found eligible. A validated questionnaire, Hydrocephalus Outcome Questionnaire, was used to evaluate patients' QoL.<\/jats:p><jats:p>\n          Results\u2003This study included pediatric patients with a mean age of 6.54 years and a standard deviation of\u2009\u00b1\u20092.64. The male-to-female ratio was 27:25; 2% of patients had congenital or tumor-induced hydrocephalus, while cases of meningitis, encephalocele, and encephalitis accounted for 8, 4, and 2%, respectively. Myelomeningocele had the highest prevalence at 16%. The overall health scores range from 0.39 to 0.51. Social, cognitive, and physical health scores have mean values of 0.54, 0.50, and 0.48, respectively. The minimum physical health score is 0.17, indicating the most significant impact of hydrocephalus on physical function.<\/jats:p><jats:p>\n          Conclusion\u2003This study highlights variations in hydrocephalus severity among pediatric patients, impacting their overall QoL, primarily physical and behavioral functioning. Worse health outcomes were associated with frequent seizures, prolonged hospital stays for diagnosis and treatment, shunt infections, increased number of shunt catheters, and longer travel distances to medical facilities.<\/jats:p>","DOI":"10.1055\/a-2366-8580","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T23:53:56Z","timestamp":1721174036000},"page":"375-381","source":"Crossref","is-referenced-by-count":1,"title":["Assessing the Quality of Life in Hydrocephalic Children: A Study from Tertiary Care Hospitals in Pakistan"],"prefix":"10.1055","volume":"55","author":[{"given":"Arshad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lady Reading Hospital MTI, Peshawar, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameen","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafees","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6006-4159","authenticated-orcid":false,"given":"Amjad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"},{"name":"Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0404.2010.01467.x","article-title":"Clinical assessment of cerebrospinal fluid dynamics in hydrocephalus. 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