{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:05:01Z","timestamp":1784156701730,"version":"3.55.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose The most important cause of mortality and morbidity in acute\nrheumatic fever (ARF) is carditis and rheumatic heart disease (RHD). The aim of\nthis study was to identify markers that may be indicators of chronic\ninflammation in whole blood analyses in pediatric patients with RHD who\nregularly received secondary deposilin prophylaxis.<\/jats:p>\n                  <jats:p>Methods In our study, 100 children with ARF aged between 4 and 18 years\nwere followed up in the pediatric cardiology outpatient clinic of the patient\ngroup. The control group consisted of 100 healthy children of the same sex and\nage as the patient group. All children in the patient group regularly received\ndeposilin prophylaxis every 21 days. Our study included many whole blood\nparameters that are reported in the literature to represent changes in chronic\ninflammatory diseases. These parameters were CRP, RDW, PDW, MPV and leukocyte\nsubtypes, neutrophil, lymphocyte, monocyte counts and their ratios\n(neutrophil\/lymphocyte, platelet\/lymphocyte and monocyte\/lymphocyte).<\/jats:p>\n                  <jats:p>Results Leukocyte count, lymphocyte count, basophil count, MLR and\nbasophil count were significantly lower in the patient group than in the control\ngroup (p: 0.047, p: 0.023, p: 0.006). In addition, eosinophil count and RDW\nvalue were significantly higher in the patient group than in the control group\n(p: 0.043; p: 0.001).<\/jats:p>\n                  <jats:p>Conclusion In our study, low leukocyte, lymphocyte, basophil, MLR and\nhigher eosinophil counts indicated that RDW could be effectively used as a\nmarker for regular depositilin prophylaxis in pediatric patients with RHD.<\/jats:p>","DOI":"10.1055\/a-2367-9190","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T19:58:26Z","timestamp":1721246306000},"page":"191-195","source":"Crossref","is-referenced-by-count":0,"title":["Role of Parameters in Whole Blood Analysis as in Indicator of\nSystemic Inflammation in Children with Rheumatic Valve Diseases"],"prefix":"10.1055","volume":"238","author":[{"given":"Lala","family":"Nurmammadova","sequence":"additional","affiliation":[{"name":"Pediatrics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilmaz","family":"Yozgat","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Istanbul Medipol University, Istanbul,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-0261","authenticated-orcid":false,"given":"Can Yilmaz","family":"Yozgat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Bezmialem Vakif University, Istanbul,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turkay","family":"Babayeva","sequence":"additional","affiliation":[{"name":"Pediatrics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigar","family":"Bayramova","sequence":"additional","affiliation":[{"name":"Pediatrics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Talebazadeh","sequence":"additional","affiliation":[{"name":"Pediatrics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertan","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Biostaticts, National Statistical Systems Training Academy, Istanbul,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza Ustabas","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Pediatrics, Istanbul Medipol University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Erenberk","sequence":"additional","affiliation":[{"name":"Pediatrics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(05)66874-2","article-title":"Acute rheumatic fever","volume":"366","author":"J R Carapetis","year":"2005","journal-title":"Lancet."},{"key":"ref2","first-page":"590","volume-title":"Jenson. 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