{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T15:40:04Z","timestamp":1730821204459,"version":"3.28.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n            Hintergrund und Zielsetzung\u2002Erh\u00f6hte Leberwerte (ELW) sind in Deutschland h\u00e4ufig. \u00c4rzten der Prim\u00e4rversorgung kommt eine besondere Rolle in der Fr\u00fcherkennung von Lebererkrankungen zu. Ziel dieses Artikels ist es, eine \u00dcbersicht f\u00fcr \u00c4rzte im prim\u00e4r\u00e4rztlichen Sektor \u00fcber autoimmune Lebererkrankungen zu schaffen, mit dem Fokus auf die Labordiagnostik.<\/jats:p><jats:p>\n            Methode\u2002Als Referenz dienen die nationalen und internationalen Leitlinien und \u00dcbersichtsartikel, erg\u00e4nzt durch die aktuellen Pr\u00e4valenzdaten des Zentralinstituts kassen\u00e4rztliche Vereinigung (ZI).<\/jats:p><jats:p>\n            Ergebnisse\u2002Im Jahr 2022 erhielten von den rund 59 Millionen prim\u00e4r\u00e4rztlichen Patienten ab dem 20. Lebensjahr ca. 50\u201360\/100\u200a000 eine gesicherte Diagnose einer Autoimmun-Hepatitis oder prim\u00e4r bili\u00e4ren Cholangitis (nach ICD-10-GM-Diagnose). Die Diagnosen wurden bei Frauen 2- bis 6-mal h\u00e4ufiger gestellt als bei M\u00e4nnern. Die prim\u00e4r sklerosierende Cholangitis kam bei rund 10\/100\u200a000 prim\u00e4r\u00e4rztlichen behandelten Personen vor; Frauen waren bis zu 2-mal h\u00e4ufiger betroffen, insbesondere ab einem Lebensalter von 60 Jahren. Daten zu \u00c4tiologie, Klinik, labordiagnostischen Parametern, Therapiem\u00f6glichkeiten und Prognosedaten zu den 3 Krankheitsentit\u00e4ten werden in diesem Artikel in K\u00fcrze dargestellt.<\/jats:p><jats:p>\n            Schlussfolgerung\u2002Die Labordiagnostik ist f\u00fcr die Diagnose autoimmuner Lebererkrankungen der zentrale Schritt. Ein generelles Laborwerte-Screening bei ELW ist jedoch nicht ratsam. Vielmehr muss bedacht werden, dass f\u00fcr diese Marker in der prim\u00e4r\u00e4rztlichen Versorgung bislang keine validierten Kennzahlen vorliegen. Die Interpretation dieser Laborwerte ist also komplex. Es ist deshalb ratsam, unter Ber\u00fccksichtigung der h\u00e4ufigen (und weniger h\u00e4ufigen) Ursachen, die zu ELW f\u00fchren k\u00f6nnen, eine Bestimmung dieser speziellen Laborparameter in Betracht zu ziehen.<\/jats:p>","DOI":"10.1055\/a-2367-9603","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:45:13Z","timestamp":1728560713000},"page":"1282-1286","source":"Crossref","is-referenced-by-count":0,"title":["Prim\u00e4r\u00e4rztliche Labordiagnostik autoimmuner Lebererkrankungen \u2013 Short review"],"prefix":"10.1055","volume":"149","author":[{"given":"Dirk","family":"Mo\u00dfhammer","sequence":"additional","affiliation":[{"name":"Hausarztpraxis Oferdingen, Lindberghstra\u00dfe 3, 72768\u00a0Reutlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias Christian","family":"Reichert","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Gastroenterologie, Hepatologie und Allgemeinmedizin, Hauptstr. 30, 71154 Nufringen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2015.12.023","article-title":"Association between hepatic steatosis and serum liver enzyme levels with atrial fibrillation in the general population. 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