{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:48:33Z","timestamp":1775666913873,"version":"3.50.1"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004786","name":"ODAS Stichting","doi-asserted-by":"crossref","award":["Grant number 2021-32327"],"award-info":[{"award-number":["Grant number 2021-32327"]}],"id":[{"id":"10.13039\/501100004786","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n            Objective\u2003Neonatal sepsis has been established as a risk factor for retinopathy of prematurity (ROP) but previous meta-analyses have predominately focused on late-onset sepsis (LOS). This meta-analysis aims to explore the association between early-onset sepsis (EOS) and the risk of ROP.<\/jats:p><jats:p>\n            Study Design\u2003Observational studies reporting (unadjusted) data on proven EOS in neonates with ROP were included. PubMed, Embase, and Cochrane Library were searched. Proven EOS was defined as a positive blood or cerebrospinal fluid culture. Effect sizes were calculated by using logistic random-effects models and meta-regression analyses. Primary outcomes were any stage ROP and severe ROP (\u2265stage 3, type I, aggressive [posterior] ROP, plus disease or requiring treatment). Potential confounders explored were gestational age at birth, birth weight, small for gestational age, maternal steroid use, necrotizing enterocolitis, LOS, and mechanical ventilation duration.<\/jats:p><jats:p>\n            Results\u2003Seventeen studies reporting the incidence of proven EOS in neonates with ROP were included. Proven EOS showed no significant association with any stage ROP (odds ratio [OR]\u2009=\u20091.90; 95% confidence interval [CI]: 0.96\u20133.79, p\u2009=\u20090.067) but heterogeneity between studies was significantly high. Neonates with proven EOS had an increased risk for severe ROP (OR\u2009=\u20092.21; 95% CI: 1.68\u20132.90), and no significant confounders influencing this effect size were found in the meta-regression analysis.<\/jats:p><jats:p>\n            Conclusion\u2003Neonates with proven EOS are at increased risk of severe ROP. Neonatologists need to be aware that EOS is an early predictor of ROP and should adapt their policy and treatment decisions where possible to reduce ROP.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2369-6690","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:02:32Z","timestamp":1721433752000},"page":"387-394","source":"Crossref","is-referenced-by-count":1,"title":["Early-Onset Sepsis as an Early Predictor for Retinopathy of Prematurity: A Meta-analysis"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-2256","authenticated-orcid":false,"given":"Salma","family":"El Emrani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte E.","family":"van der Meeren","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther J.S.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Women and Neonate, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle J.","family":"Goeman","sequence":"additional","affiliation":[{"name":"Medical Statistics, Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline U.M.","family":"Termote","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Women and Neonate, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoline E.","family":"Schalij-Delfos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The 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