{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:46:32Z","timestamp":1766155592465,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"crossref","award":["MED- 345- 2023"],"award-info":[{"award-number":["MED- 345- 2023"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n            Objective\u2003Neonates with moderate-to-severe perinatal asphyxia often develop acute kidney injury (AKI). Additionally, therapeutic hypothermia (TH) can affect renal blood flow. This study aimed to evaluate the association between renal regional oxygen saturation (rSrO2) during TH and AKI in neonates with moderate and severe perinatal asphyxia.<\/jats:p><jats:p>\n            Study Design\u2003This retrospective longitudinal study included neonates with moderate-to-severe asphyxia who required TH. The primary outcome was the occurrence of AKI, classified as a rate of decrease in creatinine levels of &lt;33% at 72\u2009hours of TH. rSrO2 was continuously monitored by near-infrared spectroscopy during the hypothermia and rewarming phases. Data analysis involved dividing the average rSrO2 levels into 12-hour periods. We analyzed the association between AKI and rSrO2 levels using univariate and multivariate logistic regression models. Furthermore, we assessed the predictive capacity of rSrO2 for AKI by analyzing the area under the receiver operating characteristic curve.<\/jats:p><jats:p>\n            Results\u2003Ninety-one patients were included in the study. On average, patients with AKI exhibit lower rSrO2 levels during TH. Specifically, rSrO2 levels within the first 12\u2009hours and between 25 and 72\u2009hours of TH demonstrated the highest predictive capability for AKI. Multivariate logistic regression analysis revealed that rSrO2 levels within the initial 12\u2009hours (adjusted odds ratio [aOR]\u2009=\u20091.11, 95% confidence interval [CI]: 1.01\u20131.21) and between 61 and 72\u2009hours (aOR\u2009=\u20090.85, 95% CI: 0.78\u20130.92) were significantly associated with AKI.<\/jats:p><jats:p>\n            Conclusion\u2003An increase in rSrO2 during the first 12\u2009hours of TH and lower rSrO2 levels between 61 and 72\u2009hours of treatment were associated with the development of AKI in asphyxiated neonates undergoing TH.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2369-6811","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:02:32Z","timestamp":1721433752000},"page":"379-386","source":"Crossref","is-referenced-by-count":1,"title":["Renal Regional Oxygen Saturation and Acute Kidney Injury in Neonates with Perinatal Asphyxia"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-4529","authenticated-orcid":false,"given":"Sergio","family":"Agudelo-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de La Sabana, Chia, Colombia"},{"name":"Neonatal Unit, Fundaci\u00f3n Cardio Infantil\u2014Instituto de Cardiolog\u00eda, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Fundaci\u00f3n Cardio Infantil\u2014Instituto de Cardiolog\u00eda, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Botero-Rosas","sequence":"additional","affiliation":[{"name":"Department of Bioscience, School of Medicine, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Valentina","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals","volume":"6","author":"J Perin","year":"2022","journal-title":"Lancet Child Adolesc Health"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.clp.2016.04.003","article-title":"Perinatal asphyxia from the obstetric standpoint: diagnosis and interventions","volume":"43","author":"C A Herrera","year":"2016","journal-title":"Clin Perinatol"},{"issue":"04","key":"ref3","first-page":"280.e1","article-title":"Neonatal multiple organ failure after perinatal asphyxia","volume":"97","author":"I 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