{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:43:36Z","timestamp":1767919416320,"version":"3.49.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Bei einem Teil der Patienten mit SARS-CoV-2-Infektion (COVID-19) erfolgte w\u00e4hrend der station\u00e4ren Betreuung eine invasive Beatmung. Die Entw\u00f6hnung von der Beatmung gestaltete sich bei einigen Patienten schwierig (sog. prolongiertes Weaning).<\/jats:p>\n                  <jats:p>Patienten Wir haben retrospektiv Patientencharakteristika und Outcome\n      von 193 Patienten mit COVID-19-assoziierter invasiver Beatmung mit prolongiertem Weaning an\n      vier deutschen Weaning-Zentren erfasst. Als Vergleichsgruppe wurden Patienten (n=751) mit\n      prolongiertem Weaning (Grund der Beatmung \u201ePneumonie\u201c und \u201eAkutes Lungenversagen\u201c) aus diesen\n      vier Zentren aus den Jahren 2011\u20132023 aus dem \u201eWeanNet\u201c-Register herangezogen.<\/jats:p>\n                  <jats:p>Ergebnisse Im Median betrug die intensivmedizinische Betreuung 39 (25\u201368) Tage. Bei 19% (37\/193) der Patienten war im Median f\u00fcr 27 (18\u201351) Tage eine ECMO-Unterst\u00fctzung notwendig. Die Sterblichkeit im Krankenhaus betrug 8,3% (2,7% mit vs. 9,6% ohne ECMO) und in der Vergleichsgruppe verstarben 6,8%. Bei Entlassung waren 84% (Vergleichsgruppe 77%) komplett entw\u00f6hnt, bei 2,6% (Vergleichsgruppe 17,6%) der Patienten erfolgte eine NIV-Behandlung. Bei 7,8% (Vergleichsgruppe 15,7%) war weiterhin eine invasive Beatmung notwendig. Im Beobachtungszeitraum von 6 Monaten nach Entlassung war bei 22,4% und nach 12 Monaten bei weiteren 14,1% der Patienten eine station\u00e4re Betreuung notwendig. Die Gesamtsterblichkeit im Follow-up nach 12 Monaten betrug 20,6% (5,6% mit vs. 24,6% ohne ECMO).<\/jats:p>\n                  <jats:p>Diskussion Die Sterblichkeit von beatmeten Patienten mit COVID-19 war\n      in den vier untersuchten Weaning-Zentren mit 8,3% sehr gering. Die Sterblichkeit der Patienten\n      mit einer ECMO-Behandlung lag bei lediglich 2,7%. Die Sterblichkeit in der Vergleichsgruppe\n      wurde mit 7,3% ermittelt. Die geringere Sterblichkeit der Patienten mit einer ECMO-Behandlung\n      zeigte sich auch bei Nachbeobachtung mit bis zu 12 Monaten.<\/jats:p>\n                  <jats:p>Die aufgrund von COVID-19 invasiv beatmeten Patienten mit prolongiertem Weaning zeigten sowohl hinsichtlich erfolgreicher Entw\u00f6hnung als auch im Hinblick auf die Sterblichkeit vergleichbare Ergebnisse im Vergleich zu einer Kontrollgruppe aus dem WeanNet-Register. Die Langzeitergebnisse mit einem \u00dcberleben von mehr als 80% f\u00fcr das erste Jahr nach Entlassung waren ermutigend.<\/jats:p>","DOI":"10.1055\/a-2370-1763","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T18:53:55Z","timestamp":1723748035000},"page":"80-86","source":"Crossref","is-referenced-by-count":2,"title":["Prolongierte Entw\u00f6hnung nach Langzeitbeatmung aufgrund einer SARS-CoV-2-Infektion \u2013 eine multizentrische retrospektive Analyse"],"prefix":"10.1055","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0952-0841","authenticated-orcid":false,"given":"Florian","family":"Geismann","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Pneumologie, Klinik Donaustauf, Donaustauf, Deutschland"},{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Braunschmidt","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Pneumologie, Klinik Donaustauf, Donaustauf, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Mohr","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Pneumologie, Klinik Donaustauf, Donaustauf, Deutschland"},{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"},{"name":"Klinik f\u00fcr Pneumologie, Beatmungsmedizin und Infektiologie, Innklinikum M\u00fchldorf, M\u00fchldorf am Inn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Hardebusch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Lungenklinik Hemer, Hemer, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Lungenklinik Hemer, Hemer, Deutschland"},{"name":"Private University Witten\/Herdecke, Witten, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dreher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie und internistische Intensivmedizin, Uniklinik RWTH Aachen, Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-3496","authenticated-orcid":false,"given":"Tobias","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medizinische Klinik V, Universit\u00e4tsklinikum Mannheim, Mannheim, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Heine","sequence":"additional","affiliation":[{"name":"Internal Medicine 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