{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:26:19Z","timestamp":1775784379108,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Hospital training to revitalize research\n                        projects","award":["201905"],"award-info":[{"award-number":["201905"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to assess the efficacy and safety of a combined recombinant\n                    human parathyroid hormone 1\u201334 [rhPTH (1\u201334)] and vitamin K2 therapy versus\n                    vitamin K2 alone in the treatment of postmenopausal osteoporosis. A total of 77\n                    postmenopausal osteoporosis patients were randomly divided into two groups.\n                    Patients in one group received vitamin K2 alone, while patients in the other\n                    group received a combination of rhPTH (1\u201334) and vitamin K2. Bone mineral\n                    density (BMD), electrolyte levels, pain scores, bone metabolism levels, and\n                    adverse drug reactions were compared pre- and post-treatment. Both two\n                    treatments improved BMD, blood calcium concentrations, pain scores, and\n                    increased osteocalcin and osteoprotegerin levels. Notably, the combined rhPTH\n                    (1\u201334) and vitamin K2 treatment demonstrated superior efficacy in improving BMD\n                    and bone metabolism markers. Furthermore, there was no significant difference in\n                    the incidence of adverse reactions between the two groups, indicating the safety\n                    of the combined treatment. In summary, the combined therapy of rhPTH (1\u201334) and\n                    vitamin K2 exhibited more potent efficacy in the treatment of postmenopausal\n                    osteoporosis, more effectively enhancing BMD and bone metabolism markers than\n                    vitamin K2 alone, without a significant increase in adverse reactions.<\/jats:p>","DOI":"10.1055\/a-2371-1642","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T22:41:20Z","timestamp":1724884880000},"page":"33-38","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Recombinant Human Parathyroid Hormone 1\u201334 and Vitamin K2\n                    Combination Therapy in Postmenopausal Osteoporosis"],"prefix":"10.1055","volume":"57","author":[{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Surgery of Spine and Bone Tumors, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Xia","sequence":"additional","affiliation":[{"name":"Surgery of Spine and Bone Tumors, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Gong","sequence":"additional","affiliation":[{"name":"Surgery of Spine and Bone Tumors, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruopeng","family":"Mai","sequence":"additional","affiliation":[{"name":"Surgery of Spine and Bone Tumors, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Surgery of Spine and Bone Tumors, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaogang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, People\u2019s Hospital of Ningxia Hui\n                    Autonomous Region, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12905-019-0808-0","article-title":"Association of breastfeeding and postmenopausal osteoporosis in Chinese women: a\n                    community-based retrospective study","volume":"19","author":"G Yan","year":"2019","journal-title":"BMC Womens Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e0248020","DOI":"10.1371\/journal.pone.0248020","article-title":"Prevalence and diagnosis experience of osteoporosis in postmenopausal women over\n      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Rechnol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in\n                    postmenopausal women with osteoporosis","volume":"344","author":"R M Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e13341","DOI":"10.1097\/MD.0000000000013341","article-title":"Efficacy and safety of recombinant human parathyroid hormone (1-34) are similar\n                    to those of alendronate in the treatment of postmenopausal osteoporosis","volume":"97","author":"J Deng","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref18","first-page":"w13952","article-title":"The role of teriparatide in sequential and combination therapy of\n                    osteoporosis","volume":"144","author":"C Meier","year":"2014","journal-title":"Swiss medical 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and Harris hip\n                    score in patients with femoral head necrosis","volume":"13","author":"F Li","year":"2021","journal-title":"Am J Transl Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.33549\/physiolres.934779","article-title":"Parathyroid hormone-related changes of bone structure","volume":"70","author":"M Ku\u017ema","year":"2021","journal-title":"Physiol Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00223-010-9424-6","article-title":"Pharmacokinetics of teriparatide (rhPTH[1-34]) and calcium pharmacodynamics in\n                    postmenopausal women with osteoporosis","volume":"87","author":"J Satterwhite","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1742-1241.2003.tb10593.x","article-title":"Teriparatide (rhPTH 1-34) for the treatment of osteoporosis","volume":"57","author":"P R Ebeling","year":"2003","journal-title":"Int J Clin Pract"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00774-022-01342-6","article-title":"Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at\n                    a long-term follow-up: meta-analysis and systematic review","volume":"40","author":"M Zhou","year":"2022","journal-title":"J Bone Miner Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1515\/jpem-2020-0637","article-title":"Effect of vitamin K2 and vitamin D3 on bone mineral density in children with\n                    acute lymphoblastic leukemia: a prospective cohort study","volume":"34","author":"I Solmaz","year":"2021","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/jpm13050705","article-title":"Biomarkers for prostate cancer bone metastasis detection and prediction","volume":"13","author":"M Ying","year":"2023","journal-title":"J Pers Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jconrel.2022.07.012","article-title":"Enhanced oral absorption of teriparatide with therapeutic potential for\n                    management of osteoporosis","volume":"349","author":"L Subedi","year":"2022","journal-title":"J Control Release"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2371-1642.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T23:31:35Z","timestamp":1736551895000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2371-1642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":29,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,1,10]]},"published-print":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2371-1642","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]}}}