{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:30:01Z","timestamp":1782739801272,"version":"3.54.5"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002Preeclampsia, whose pathophysiology is still not fully\n                    elucidated today, is a pregnancy-specific disease that affects most organ\n                    systems in pregnant women, including the central nervous system. In this\n                    context, we aimed to investigate the effects of preeclampsia on blood flow in\n                    the ophthalmic artery of the eye, which is considered a part of the central\n                    nervous system.<\/jats:p><jats:p>\n          Materials and Methods\u2002This prospective, non-interventional cohort study\n                    was conducted between February 2022 and June 2022 at Umraniye Training and\n                    Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.\n                    Forty-six normotensive healthy pregnant women constituted the control group and\n                    46 preeclamptic pregnant women constituted the preeclampsia group. Prenatal\n                    follow-up and delivery of the participants were carried out in our clinic.\n                    First, an obstetric ultrasound was performed on all participants with the same\n                    ultrasound device and the same clinician. Then, Doppler measurements of the\n                    ophthalmic artery of both eyes were made by the same clinician using the linear\n                    probe of the same ultrasound. Both groups were compared in terms of the first\n                    peak of systolic velocity (PSV), second PSV, pulsatility index (PI), PSV ratio,\n                    end-diastolic velocity (EDV), resistance index (RI), and systolic\/diastolic\n                    ratio (S\/D) measurements of the ophthalmic artery.<\/jats:p><jats:p>\n          Results\u2002The first PSV, second PSV, PSV ratio, and EDV were significantly\n                    higher in the preeclampsia group than in the control group (p=0.001, p&lt;0.001,\n                    p=0.019, p&lt;0.001, respectively). According to the receiver operating\n                    characteristic analysis, the second PSV with a cut-off value of 43.75 cm\/s was\n                    the most powerful ophthalmic artery Doppler parameter in detecting preeclampsia\n                    with 63% sensitivity and 63% specificity. No significant difference was found\n                    between the early and late onset or mild and severe preeclampsia groups in terms\n                    of ophthalmic artery Doppler parameters.<\/jats:p><jats:p>\n          Conclusion\u2002Although the number of participants was too small to draw a\n                    definitive conclusion, the second PSV seems to be the most powerful parameter\n                    for the detection of preeclampsia. Studies with larger series are needed to\n                    determine the usability of ophthalmic artery Doppler parameters in the routine\n                    clinical diagnosis of preeclampsia and follow-up of the disease.<\/jats:p>","DOI":"10.1055\/a-2371-1856","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T23:04:05Z","timestamp":1724108645000},"page":"22-28","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Ophthalmic Artery Doppler Parameters in Preeclamptic\n                    and Normotensive Pregnant Women"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5866-5959","authenticated-orcid":false,"given":"Asl\u0131","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Umraniye\n                    Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-1049","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"\u00d6zel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal Fetal\n                    Unit, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-0838","authenticated-orcid":false,"given":"Cem","family":"Yal\u00e7\u0131nkaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Umraniye\n                    Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2041-1037","authenticated-orcid":false,"given":"Safa","family":"\u00d6zy\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Umraniye Training and Research\n                    Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Umraniye\n                    Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-375X","authenticated-orcid":false,"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal Fetal\n                    Unit, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/586578","article-title":"Preeclampsia 2012","volume":"2012","author":"E Eiland","year":"2012","journal-title":"J Pregnancy"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"E Dimitriadis","year":"2023","journal-title":"Nat Rev Dis Primer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S786","DOI":"10.1016\/j.ajog.2021.12.001","article-title":"Preeclampsia and eclampsia: the conceptual evolution of a syndrome","volume":"226","author":"O Erez","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11916-021-00958-z","article-title":"Neurology of Preeclampsia and related disorders: an update in\n                    neuro-obstetrics","volume":"25","author":"E C Miller","year":"2021","journal-title":"Curr Pain Headache Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global \u0131mpact of pre-eclampsia and eclampsia","volume":"33","author":"L Duley","year":"2009","journal-title":"Semin Perinatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.21673\/anadoluklin.252168","article-title":"Posteriyor Reversibl Ensefalopati Sendromu (PRES) ve Hayat Kurtar\u0131c\u0131 Yo\u011fun Bak\u0131m\n                    \u00dcnitesi","volume":"22","author":"M \u00c7al\u0131m","year":"2017","journal-title":"Anadolu Klin T\u0131p Bilim Derg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1258\/om.2012.120007","article-title":"Renin-angiotensin system in pre-eclampsia: everything old is new again","volume":"5","year":"2012","journal-title":"Obstet Med Med Pregnancy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/uog.17209","article-title":"Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of\n                    women with pre-eclampsia","volume":"49","author":"S C Kane","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/sj.eye.6700651","article-title":"Reproducibility of blood flow velocity measurements using colour decoded Doppler\n                    imaging","volume":"18","author":"E T Matthiessen","year":"2004","journal-title":"Eye"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"879","DOI":"10.7863\/jum.2012.31.6.879","article-title":"Doppler velocimetry of the ophthalmic artery: Reproducibility of blood flow\n                    velocity measurements","volume":"31","author":"C A De Oliveira","year":"2012","journal-title":"J Ultrasound Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3109\/10641955.2015.1116553","article-title":"Prospective study of the hemodynamic behavior of ophthalmic arteries in\n                    postpartum preeclamptic women: A doppler evaluation","volume":"35","author":"J H Alves Borges","year":"2016","journal-title":"Hypertens Pregnancy"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1002\/jum.15241","article-title":"What \u0131s the role of the maternal ophthalmic and cervical \u0131nternal carotid\n                    arteries in predicting maternal adverse outcomes in preeclampsia?","volume":"39","author":"M E Ozdemir","year":"2020","journal-title":"J Ultrasound Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"9078","DOI":"10.1080\/14767058.2021.2014452","article-title":"Performance of ophthalmic artery Doppler velocimetry in the complementary\n                    diagnosis of preeclampsia","volume":"35","author":"AL D Diniz","year":"2024","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.15557\/JoU.2020.0015","article-title":"Comparison of the resistive indices obtained in the uterine artery and the\n                    ophthalmic artery in preeclamptic and normotensive patients in Doppler US","volume":"20","author":"S R Madina","year":"2020","journal-title":"J Ultrason"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0002-9378(99)70261-9","article-title":"Effects of blood pressure on orbital and middle cerebral artery resistances in\n                    healthy pregnant women and women with preeclampsia","volume":"180","author":"M A Belfort","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12884-023-05656-9","article-title":"Ophthalmic artery Doppler in the complementary diagnosis of preeclampsia: a\n                    systematic review and meta-analysis","volume":"23","author":"PFM V De Melo","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary,\n                    Number 222","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1148\/radiology.173.2.2678264","article-title":"Color Doppler flow imaging of the normal and abnormal orbit","volume":"173","author":"S J Erickson","year":"1989","journal-title":"Radiology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/uog.23528","article-title":"Ophthalmic artery Doppler in combination with other biomarkers in prediction of\n                    pre-eclampsia at 19\u201323 weeks\u2019 gestation","volume":"57","author":"I Sapantzoglou","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/0140-6736(92)93268-R","article-title":"Ophthalmic artery velocimetry in pregnant women","volume":"340","author":"T Hata","year":"1992","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S0002-9378(97)70458-7","article-title":"Maternal ophthalmic artery Doppler velocimetry in normotensive pregnancies and\n                    pregnancies complicated by hypertensive disorders","volume":"177","author":"T Hata","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ijgo.14305","article-title":"Diagnostic value of ophthalmic artery Doppler indices for prediction of\n                    preeclampsia at 28\u201332 weeks of gestation","volume":"160","author":"M Saleh","year":"2023","journal-title":"Int J Gynecol Obstet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S0720-048X(02)00194-8","article-title":"Ophthalmic artery color Doppler ultrasonography in mild-to-moderate\n                    preeclampsia","volume":"46","author":"T Ayaz","year":"2003","journal-title":"Eur J Radiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2147\/IJWH.S86314","article-title":"Maternal ophthalmic artery Doppler velocimetry in pre-eclampsia in Southwestern\n                    Nigeria","author":"A Adekanmi","year":"2015","journal-title":"Int J Womens Health"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/uog.19002","article-title":"Ophthalmic artery Doppler for prediction of pre-eclampsia: systematic review and\n                    meta-analysis","volume":"51","author":"E Kalafat","year":"2018","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2371-1856.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:57:58Z","timestamp":1738886278000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2371-1856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":25,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,2,6]]},"published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2371-1856","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}