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Da es beim Altern im Rahmen einer mitochondrialen Dysfunktion ebenfalls zu einer niedriggradigen chronischen Entz\u00fcndungsreaktion kommt (Inflamm-Aging), \u00fcberlagern sich diese entz\u00fcndlichen Prozesse im Alter und verst\u00e4rken die glaukomassoziierten pathophysiologischen Vorg\u00e4nge. Um aktiv diesen Entz\u00fcndungsereignissen entgegenzuwirken, soll die Therapie von vorhandenen Systemerkrankungen optimiert, die Chronobiologie eingehalten und das Mikrobiom verbessert werden. Hierf\u00fcr unterst\u00fctzend sind eine erh\u00f6hte physische und mentale Aktivit\u00e4t. Somit ist neben einer personalisierten zieldruckorientierten Augeninnendrucksenkung auch eine holistische Sichtweise erforderlich, um der Neurodegeneration prim\u00e4res Offenwinkelglaukom\n          therapeutisch gerecht zu werden.<\/jats:p>","DOI":"10.1055\/a-2372-3505","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T23:24:55Z","timestamp":1724801095000},"page":"661-670","source":"Crossref","is-referenced-by-count":0,"title":["Lifestyle Changes in Aging and their Potential Impact on POAG"],"prefix":"10.1055","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-1264","authenticated-orcid":false,"given":"Carl","family":"Erb","sequence":"additional","affiliation":[{"name":"Augenklinik am Wittenbergplatz, Berlin, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clivia","family":"Erb","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avaz","family":"Kazakov","sequence":"additional","affiliation":[{"name":"External Relations and Development, Salymbekov University, Bishkek, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnara","family":"Kapanova","sequence":"additional","affiliation":[{"name":"Medical Faculty of Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Weisser","sequence":"additional","affiliation":[{"name":"Sportmedizin, Institut f\u00fcr Sportwissenschaft, Kiel, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"H A Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1758-3486","article-title":"Normaldruckglaukome","author":"V Prokosch","year":"2022","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/ceo.14043","article-title":"Normal-tension glaucoma: Current concepts and approaches - 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