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Aufgrund immer neuer molekularpathologischer und genetischer Erkenntnisse werden im Rahmen der wiederkehrenden WHO-Klassifikation der Speicheldr\u00fcsenkarzinome stetig neue Entit\u00e4ten definiert, sodass die Inzidenzraten der Entit\u00e4ten einem st\u00e4ndigen Wandel unterliegen. Der einzige gesicherte Risikofaktor f\u00fcr die Entstehung von Speicheldr\u00fcsenkarzinomen ist ionisierende Strahlung. Dar\u00fcber hinaus verschlechtern gro\u00dfe Tumoren, zervikaler Lymphknotenbefall und Perineuralscheidenbefall die Prognose signifikant. Heute r\u00fcckt die Molekularpathologie in den Vordergrund, mit der potenzielle Targets identifiziert werden konnten, die insbesondere in rezidivierten oder fernmetastasierten Stadien prognoseverbessernde Therapieoptionen bieten k\u00f6nnen. So k\u00f6nnen entit\u00e4tsspezifische Tyrosinkinase-Inhibitoren wie Axitinib beim Adenoidzystischen Karzinom oder Larotrectinib beim sekretorischen Karzinom und entit\u00e4ts\u00fcbergreifende Therapien wie HER2-Inhibition und Androgendeprivation bei g\u00fcnstigem Nebenwirkungsprofil das mediane und progressionsfreie \u00dcberleben verl\u00e4ngern.<\/jats:p>","DOI":"10.1055\/a-2373-5741","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T18:42:12Z","timestamp":1729190532000},"page":"87-93","source":"Crossref","is-referenced-by-count":1,"title":["Klinische und molekulare Epidemiologie maligner Speicheldr\u00fcsentumore"],"prefix":"10.1055","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-1099","authenticated-orcid":false,"given":"Louis","family":"Jansen","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-4511","authenticated-orcid":false,"given":"Lisa","family":"Nachtsheim","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Mayer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Arolt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Allgemeine Pathologie und Pathologische Anatomie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Quaas","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Allgemeine Pathologie und Pathologische Anatomie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Klu\u00dfmann","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Wolber","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1034\/j.1601-0825.2002.02870.x","article-title":"Salivary gland tumours","volume":"8","author":"P Speight","year":"2002","journal-title":"Oral diseases"},{"key":"ref2","first-page":"662","volume-title":"Treatment of head and neck cancers. 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Teo","year":"2000","journal-title":"Hong Kong Medical Journal"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.oooo.2016.08.008","article-title":"The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis","volume":"122","author":"J Ju","year":"2016","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"},{"key":"ref29","first-page":"180","article-title":"Br J Oral Maxillofac Surg.: Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?","volume":"55","author":"I Luksic","year":"2014","journal-title":"Croatian Medical Journal"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12105-009-0102-9","article-title":"An Update on Grading of Salivary Gland Carcinomas","volume":"3","author":"RR 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Sheth","year":"2021","journal-title":"JCO Precision Oncology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/annonc\/mdx771","article-title":"A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma","volume":"29","author":"C Fushimi","year":"2018","journal-title":"Annals of Oncology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejca.2018.12.035","article-title":"Adjuvant androgen deprivation therapy for poor-risk, androgen receptor\u2013positive salivary duct carcinoma","volume":"110","author":"W Van Boxtel","year":"2019","journal-title":"European journal of cancer"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s12105-018-0984-5","article-title":"Expression of PTEN, androgen receptor, HER2\/neu, cytokeratin 5\/6, estrogen receptor-beta, HMGA2, and PLAG1 in salivary duct 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