{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:50:19Z","timestamp":1782514219705,"version":"3.54.5"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die bipolare St\u00f6rung ist eine schwere psychische Erkrankung, die h\u00e4ufig mit\n                    Komorbidit\u00e4ten wie Angst oder Alkoholabh\u00e4ngigkeit vergesellschaftet ist. Somit\n                    k\u00f6nnte der Einsatz von Pregabalin vielversprechend sein. Wir pr\u00e4sentieren den\n                    Fallbericht einer 37j\u00e4hrigen Frau mit einer Bipolar II St\u00f6rung w\u00e4hrend einer\n                    depressiven Episode begleitet von Angstsymptomen und zunehmendem Alkoholkonsum.\n                    Die medikament\u00f6se Behandlung bestand aus einer Monotherapie mit Quetiapin. Nach\n                    einigen Tagen mit zus\u00e4tzlicher Gabe von Pregabalin beobachteten wir zunehmende\n                    Suizidgedanken sowie selbstverletzendes Verhalten, obwohl die Angstsymptome und\n                    der Alkoholkonsum r\u00fcckl\u00e4ufig waren. Wir beendeten die Therapie mit Pregabalin\n                    und erh\u00f6hten die Dosis von Quetiapin, hierauf verschwand das suizidale Verhalten\n                    fast vollst\u00e4ndig. Ein Blick in die Literatur zeigt noch Uneinigkeit. Einerseits\n                    wird Pregabalin als sicheres und gut toleriertes Medikament beschrieben und\n                    andererseits bestehen Bedenken hinsichtlich suizidaler Effekte antikonvulsiver\n                    Medikamente. Schlussfolgernd empfehlen wir den vorsichtigen Einsatz von\n                    Pregabalin sowie weiterer antikonvulsiver Medikamente bei Patienten mit\n                    affektiven St\u00f6rung. Pregabalin k\u00f6nnte einen positiven Effekt auf die\n                    Komorbidit\u00e4ten haben, der Effekt auf die Stimmung verbleibt jedoch noch unklar.\n                <\/jats:p>","DOI":"10.1055\/a-2374-2182","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T23:17:25Z","timestamp":1724973445000},"page":"53-56","source":"Crossref","is-referenced-by-count":2,"title":["Aufkommende Suizidgedanken einer bipolaren Patientin nach Einnahme\n                    von Pregabalin: ein Fallbericht"],"prefix":"10.1055","volume":"93","author":[{"given":"Christine","family":"Wagner","sequence":"additional","affiliation":[{"name":"Avi Medical, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Montecino","sequence":"additional","affiliation":[{"name":"Psychiatrie, HELIOS Klinikum Pirna, Pirna,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e5636","DOI":"10.7759\/cureus.5636","article-title":"Medical and Psychiatric Comorbidities in Bipolar Disorder: Insights from\n                    National Inpatient Population-based Study","volume":"11","author":"S Hossain","year":"2019","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/13543784.2018.1417383","article-title":"Gabapentin for the treatment of alcohol use disorder","volume":"27","author":"B J Mason","year":"2018","journal-title":"Expert Opin Investig Drugs"},{"key":"ref3","volume-title":"Pregabalin. 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