{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:25:49Z","timestamp":1764231949906,"version":"3.46.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The impact of surgical margins on the prognosis of early breast cancer remains uncertain, particularly in the context of modern treatment approaches. This study aimed to investigate whether involved margins after surgery for early breast cancer affect overall survival.<\/jats:p>\n                  <jats:p>We conducted a retrospective analysis of 3767 patients who underwent surgery for primary breast cancer or carcinoma in situ between 2006 and 2022 at Charit\u00e9 \u2013 University Hospital Berlin. Survival analysis based on margin status and a subsequent multivariate Cox regression analysis were conducted.<\/jats:p>\n                  <jats:p>With a median follow-up of 72.2 months, clear margins were achieved in 81.4% of patients (n\u00a0=\u00a03068) after primary surgery, while 16.2% (n\u00a0=\u00a0610) required re-excision. Only 2.4% of patients (n\u00a0=\u00a089) had definitively involved margins. Margin involvement was more common in hormone receptor-positive disease, lobular subtype, carcinoma in situ, or locally advanced tumors, but less frequent in patients with previous neoadjuvant chemotherapy or triple-negative breast cancer. The Kaplan\u2013Meier survival curves showed a significant separation with worse outcomes for patients with definitive R1 resections. However, the multivariate Cox regression analysis detected no statistically significant difference in overall survival based on margin status. Breast conserving surgery (HR 0.66; 95% CI 0.54\u20130.81) and HER2 overexpression (HR 0.65; 95% CI 0.48\u20130.89) were associated with improved survival.<\/jats:p>\n                  <jats:p>Patients who underwent breast-conserving surgery in our study demonstrated favorable outcomes compared to patients after mastectomy. Although margin status did not significantly affect overall survival, larger multicenter studies are needed to evaluate the prognostic implications of margin involvement in breast cancer treatment in different tumor stages, tumor subtypes and local and systemic treatments.<\/jats:p>","DOI":"10.1055\/a-2374-2270","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T19:11:41Z","timestamp":1725304301000},"page":"837-844","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women\u2019s Medicine at Charit\u00e9 \u2013 University Hospital Berlin"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-0046","authenticated-orcid":false,"given":"Maximilian Heinz","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Breast Center, Campus Mitte, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline Barbara Stephanie","family":"Weiler","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Breast Center, Campus Mitte, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Trelinska-Finger","sequence":"additional","affiliation":[{"name":"Cancer Registry Charit\u00e9, Comprehensive Cancer Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Uwe","family":"Blohmer","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Breast Center, Campus Mitte, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"F Bray","year":"2024","journal-title":"CA Cancer J 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A systematic review","volume":"46","author":"J Bundred","year":"2020","journal-title":"Eur J Surg Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e076022","DOI":"10.1136\/bmj-2023-076022","article-title":"Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study","volume":"383","author":"R Schmitz","year":"2023","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e561","DOI":"10.1016\/j.ijrobp.2011.02.021","article-title":"Subsets of women with close or positive margins after breast-conserving surgery with high local recurrence risk despite breast plus boost radiotherapy","volume":"81","author":"K Lupe","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Geburtshilfe und Frauenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2374-2270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:21:06Z","timestamp":1764231666000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2374-2270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":33,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2024,9,2]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2374-2270","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0016-5751","1438-8804"],"issn-type":[{"type":"print","value":"0016-5751"},{"type":"electronic","value":"1438-8804"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}