{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:21:57Z","timestamp":1748406117227,"version":"3.41.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Die Zahl der durch humane Papillomaviren (HPV) verursachten oropharyngealen Plattenepithelkarzinome (OPSCC) hat in den letzten Jahrzehnten deutlich zugenommen. Es gibt bislang jedoch keine belastbaren Daten \u00fcber die H\u00e4ufigkeit von HPV-assoziiertem OPSCC in Mitteleuropa und dessen Behandlung.<\/jats:p><jats:p>\n          Ziel der Arbeit\u2002Die epidemiologische Erfassung von Patienten mit OPSCC und des Anteils der p16-positiven Tumoren in der Deutschen Krebsgesellschaft (DKG) zertifizierten Kopf-Hals-Tumorzentren.<\/jats:p><jats:p>\n          Material und Methoden\u2002Um die Evidenzl\u00fccke der H\u00e4ufigkeit von p16-positiven OPSCC zu schlie\u00dfen, wurde ein multizentrisches Register eingerichtet, das Patienten mit OPSCC im deutschsprachigen Raum pseudonymisiert erfasst. Die Datenerfassung erfolgt prospektiv mit Research Electronic Data Capture (REDCap).<\/jats:p><jats:p>\n          Ergebnisse\u2002Insgesamt wurden in den Jahren 2022\u20132023 1312 Patienten mit einem OPSCC aus 34 Zentren eingeschlossen. Bei 720 Patienten (58,2\u200a%) konnte p16 im Tumor nachgewiesen werden. Die h\u00e4ufigsten Lokalisationen der p16-positiven OPSCC waren mit 49,9\u200a% die Tonsille und mit 28,7\u200a% der Zungengrund. 63,1\u200a% der p16-positiven OPSCC wurden prim\u00e4r chirurgisch behandelt, wohingegen nur 48,0\u200a% der p16-negativen Tumoren prim\u00e4r operiert wurden. Bei der adjuvanten Therapie von OPSCC zeigen sich ebenfalls deutliche Unterschiede: 58\u200a% der p16-negativen OPSCC erhielten keine adjuvante Therapie nach Operation, verglichen mit nur 37,1\u200a% der p16-positiven OPSCC.<\/jats:p><jats:p>\n          Schlussfolgerung\u2002Der Start der Oropharynx-Registerstudie verlief reibungslos. Dieses Register gibt bereits jetzt einen Einblick in die aktuelle Versorgungssituation von OPSCC im deutschsprachigen Raum und wird durch die Teilnahme weiterer Zentren an Bedeutung gewinnen.<\/jats:p>","DOI":"10.1055\/a-2374-2310","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:00:52Z","timestamp":1724281252000},"page":"242-249","source":"Crossref","is-referenced-by-count":0,"title":["Das multizentrische Register \u201eOropharynxkarzinom\u201c des Deutschen Studienzentrums f\u00fcr HNO \u2013 erste Ergebnisse"],"prefix":"10.1055","volume":"104","author":[{"given":"Dirk","family":"Beutner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsmedizin G\u00f6ttingen, G\u00f6ttingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Bevis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, 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