{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:38:04Z","timestamp":1740202684424,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>W\u00e4hrend Nierenerkrankungen, die mit akuter nicht infekti\u00f6ser Entz\u00fcndung einhergehen, wie bspw. Glomerulonephritiden, bereits seit Jahrzehnten erfolgreich prim\u00e4r antiinflammatorisch behandelt werden, ist die Low-Grade-Inflammation in der Nephrologie bisher noch wenig beachtet.<\/jats:p><jats:p>Nun r\u00fcckt jedoch die pathophysiologische Bedeutung der chronischen systemischen Low-Grade-Inflammation f\u00fcr die Progression der chronischen Nierenerkrankung (CKD) und die damit verbundenen kardiovaskul\u00e4ren Komplikationen in den Vordergrund.<\/jats:p><jats:p>Antiinflammatorische Strategien haben in klinischen Studien bereits eine Effektivit\u00e4t in der Sekund\u00e4r- und Terti\u00e4rpr\u00e4vention kardiovaskul\u00e4rer Ereignisse gezeigt. Aktuelle Ver\u00f6ffentlichungen demonstrieren, dass eine Adressierung der Low-Grade-Inflammation mittels Inhibition der Interleukin-1- und Interleukin-6-Signalwege auch bei CKD-Patienten vorteilhafte Effekte auf die renale An\u00e4mie, die Progression der Nierenerkrankung sowie auf Komplikationsraten hat, ein todesursachenunabh\u00e4ngiger Mortalit\u00e4tsvorteil zeigte sich jedoch bisher nicht.<\/jats:p>","DOI":"10.1055\/a-2376-0783","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:12:46Z","timestamp":1740183166000},"page":"293-297","source":"Crossref","is-referenced-by-count":0,"title":["Therapie der Inflammation in der Nephrologie"],"prefix":"10.1055","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-5181","authenticated-orcid":false,"given":"Laura Katharina","family":"Sievers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-8355","authenticated-orcid":false,"given":"Roland","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12920-023-01702-9","article-title":"Identifying functional subtypes of IgA nephropathy based on three machine learning algorithms and WGCNA","volume":"17","author":"H Ren","year":"2024","journal-title":"BMC Med Genomics"},{"issue":"05","key":"ref2","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJMoa2314471","article-title":"Autoantibodies Targeting Nephrin in Podocytopathies","volume":"391","author":"FE Hengel","year":"2024","journal-title":"N Engl J Med"},{"issue":"07","key":"ref3","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/s41591-022-01880-6","article-title":"The promise of precision medicine in rheumatology","volume":"28","author":"JM Guthridge","year":"2022","journal-title":"Nat Med"},{"issue":"11","key":"ref4","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options","volume":"143","author":"J Jankowski","year":"2021","journal-title":"Circulation"},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1681\/ASN.0000000000000245","article-title":"Effect of Ziltivekimab on Determinants of Hemoglobin in Patients with CKD Stage 3\u20135: An Analysis of a Randomized Trial (RESCUE)","volume":"35","author":"PE Pergola","year":"2024","journal-title":"J Am Soc Nephrol"},{"issue":"08","key":"ref6","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1038\/s41591-024-03043-1","article-title":"IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial","volume":"30","author":"GM Chertow","year":"2024","journal-title":"Nat Med"},{"issue":"05","key":"ref7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.kint.2022.06.022","article-title":"Hemodialysis Novel Therapies Consortium. 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