{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:45:27Z","timestamp":1775785527265,"version":"3.50.1"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Italian Health Ministry","award":["ricerca corrente 2024"],"award-info":[{"award-number":["ricerca corrente 2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Direct endoscopic necrosectomy (DEN)\n      represents the first-line treatment for walled-off necrosis (WON). However, DEN has a\n      non-negligible rate of overall adverse events (AE) and is time-consuming due to the lack of\n      dedicated devices. This pilot study was designed to evaluate the feasibility and safety of a\n      novel dedicated device for DEN named Necrolit.<\/jats:p><jats:p>\n            Patients and methods In this multicenter retrospective\n      analysis,16 patients with WON who underwent DEN using Necrolit were compared with a control\n      group treated with non-dedicated devices. Technical success, AEs, clinical success, number of\n      procedures per patient, procedure time, and length of hospital stay were evaluated. Necrolit\n      technical performance indicators were also studied.<\/jats:p><jats:p>\n            Results Technical success was obtained in all patients in both\n      groups. In the Necrolit group, the overall AE rate was 10.1% vs. 15.9% in the control group.\n      Clinical success was 100% in the Necrolit group vs. 81.3% in the control group. Patients\n      treated with Necrolit underwent a slightly lower mean number of procedures (4.1 \u00b1 2.3 vs. 5.1\n      \u00b1 1.9) with comparable mean procedure time (67.8 \u00b1 39 minutes vs. 70.1 \u00b1 32.6 minutes). Mean\n      duration of hospital stay was 39.4 days (\u00b1 30.9) in the Necrolit group vs. 43 days (\u00b1 29.4) in\n      the control group. Device-related technical performance was rated positively.<\/jats:p><jats:p>\n            Conclusions DEN with Necrolit appears feasible and safe.<\/jats:p>","DOI":"10.1055\/a-2376-1913","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:51:15Z","timestamp":1724453475000},"page":"E962-E967","source":"Crossref","is-referenced-by-count":2,"title":["Direct endoscopic necrosectomy: Pilot study of a new dedicated device"],"prefix":"10.1055","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-0482","authenticated-orcid":false,"given":"Dario","family":"Ligresti","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-9684","authenticated-orcid":false,"given":"Cecilia","family":"Binda","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology and Digestive Endoscopy, Morgagni-Pierantoni Hospital, Forli, Italy"},{"name":"Unit of Gastroenterology and Digestive Endoscopy, Maurizio Bufalini Hospital, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Fugazza","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9289","authenticated-orcid":false,"given":"Marcello","family":"Maida","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Universit\u00e0 degli Studi di Enna 'Kore', Enna, Italy"},{"name":"Gastroenterology Unit, Umberto I Hospital, Enna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Traina","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-0031","authenticated-orcid":false,"given":"Andrea","family":"Anderloni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Viale Camillo Golgi, 19, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia (PV) 27100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy and Gastroenterology Unit, Forl\u00ec-Cesena Hospitals, Azienda Unita Sanitaria Locale della Romagna, Forl\u00ec-Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence-based guidelines for the management of acute pancreatitis","volume":"13","author":"Working Group IAP\/APA Acute Pancreatitis Guidelines","year":"2013","journal-title":"Pancreatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"D Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"E420","DOI":"10.1055\/a-1783-9229","article-title":"Endoscopic or surgical treatment for necrotizing pancreatitis: comprehensive systematic review and meta-analysis","volume":"10","author":"M Mohamadnejad","year":"2022","journal-title":"Endosc Int Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(17)32404-2","article-title":"Endoscopic or surgical step-up approach for infected necrotising pancreatitis: A multicentre randomised trial","volume":"391","author":"S van Brunschot","year":"2018","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/medicina57121305","article-title":"Direct endoscopic necrosectomy: Timing and technique","volume":"57","author":"S Pinto","year":"2021","journal-title":"Medicina"},{"key":"ref6","first-page":"574","article-title":"International multicenter comprehensive analysis of adverse events associated with lumen-apposing metal stent placement for pancreatic fluid collection drainage. Gastrointest","volume":"91","author":"A Fugazza","year":"2020","journal-title":"Endosc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"E240","DOI":"10.1055\/a-0628-6136","article-title":"The EndoRotor, a novel tool for the endoscopic management of pancreatic necrosis","volume":"50","author":"SE van der Wiel","year":"2018","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/j.gastro.2019.07.064","article-title":"American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis","volume":"158","author":"TH Baron","year":"2020","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.gie.2021.11.038","article-title":"Novel classification for adverse events in GI endoscopy: the AGREE classification","volume":"95","author":"KJ Nass","year":"2022","journal-title":"Gastrointest Endosc"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2376-1913.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:15:32Z","timestamp":1730816132000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2376-1913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":9,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,8,8]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2376-1913","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}