{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:44:30Z","timestamp":1770061470180,"version":"3.49.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412\u2009\u00b1\u20090.03), % transmittance (97%), particle size\n          (212.5\u2009\u00b1\u200905\u2009nm), zeta potential (\u2212\u200925.7\u2009\u00b1\u20091.80\u2009mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.<\/jats:p>","DOI":"10.1055\/a-2376-6380","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T23:57:36Z","timestamp":1722383856000},"page":"959-970","source":"Crossref","is-referenced-by-count":4,"title":["Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model"],"prefix":"10.1055","volume":"90","author":[{"given":"Ismail","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shafique","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Jabbar","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafi","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Superior University, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Raza","family":"Shah","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Balouch","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Gul","sequence":"additional","affiliation":[{"name":"Pharmacology Section MBC, PCSIR Laboratories Complex, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: A major and snowballing threat to public health and the economy","volume":"17","author":"C K Sen","year":"2009","journal-title":"Wound Repair Regen"},{"key":"ref2","first-page":"3706315","article-title":"Skin acute wound healing: A comprehensive 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