{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:48:55Z","timestamp":1792180135667,"version":"4.4.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endoluminal radiofrequency ablation (RFA) is a palliative treatment for patients suffering from malignant biliary obstruction (MBO). We aimed to conduct a meta-analysis to evaluate the impact of RFA on stent patency, patient survival, and adverse events.<\/jats:p><jats:p>Major databases were searched through December 2023 for patients who had undergone stenting with or without RFA for extrahepatic MBO. A random-effects model was used for analysis, with results expressed as relative risk ratios (RRs) with 95%CIs.<\/jats:p><jats:p>Nine RCTs involving 750 subjects with MBO (374 RFA plus stent vs. 376 stent only) were included. Meta-analysis revealed similar risks of stent patency at 3 months (RR 1.01, 95%CI 0.92\u20131.11; I\n                  2 = 4%) for RFA plus stenting vs. stent only. Meta-analysis showed improved survival at 6 months (RR 0.84, 95%CI 0.73\u20130.96; I\n                  2 = 21%; P = 0.01) for RFA plus stenting vs. stent only. Subgroup analysis comparing plastic vs. uncovered metal stents showed that stent patency was unaffected at 3 months (RR 1.06, 95%CI 0.91\u20131.23; I\n                  2 = 17%). Subgroup analysis showed that patients with cholangiocarcinoma experienced an overall survival benefit with RFA plus stenting vs. stenting alone (P &lt; 0.001); however, stent patency remained unaffected (P = 0.08). An increased incidence of cholecystitis was noted with RFA plus stenting vs. stenting alone (5.1% [95%CI 3.1%\u20137.8%] vs. 0.3% [95%CI 0.01%\u20131.5%], respectively).<\/jats:p><jats:p>Combining endoluminal RFA and stenting may improve overall survival in patients with MBO. RFA did not significantly impact stent patency.<\/jats:p>","DOI":"10.1055\/a-2378-9533","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T19:11:15Z","timestamp":1722625875000},"page":"272-281","source":"Crossref","is-referenced-by-count":11,"title":["Endoluminal radiofrequency ablation with stenting versus stenting alone in patients with malignant biliary obstruction: a meta-analysis of randomized trials"],"prefix":"10.1055","volume":"57","author":[{"given":"Daryl","family":"Ramai","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9289","authenticated-orcid":false,"given":"Marcello","family":"Maida","sequence":"additional","affiliation":[{"name":"Gastroenterology, S. Elia - Raimondi Hospital, Caltanissetta, Italy"},{"name":"Medicine and Surgery, Kore University of Enna, Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Medicine, Baylor Scott & White Health, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-5913","authenticated-orcid":false,"given":"Yichen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spadaccini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Previtera","sequence":"additional","affiliation":[{"name":"Donald C. Harrison Health Sciences Library, University of Cincinnati Libraries, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-6693","authenticated-orcid":false,"given":"Saurabh","family":"Chandan","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, CHI Health Creighton University Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-5124","authenticated-orcid":false,"given":"Yuting","family":"Huang","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Mayo Clinic in Florida, Jacksonville, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-5632","authenticated-orcid":false,"given":"Salih","family":"Tokmak","sequence":"additional","affiliation":[{"name":"Gastroenterology, Duzce University, Duzce, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Medicine, Lenox Hill Hospital, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"DuBroff","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ko","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Morris","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-8773","authenticated-orcid":false,"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"Medical and Surgical Sciences, University of Bologna, Bologna, Italy"},{"name":"Medicine, IRCSS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-8741","authenticated-orcid":false,"given":"Stefano Francesco","family":"Crin\u00f3","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Endoscopy of Pancreas, The Pancreas Institute, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Medical Sciences, Section of Gastroenterology, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-7448","authenticated-orcid":false,"given":"Benedetto","family":"Mangiavillano","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy, Istituto Clinico Mater Domini Casa di Cura Privata SpA, Castellanza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen A","family":"Khashab","sequence":"additional","affiliation":[{"name":"Therapeutic Endoscopy, Division of Gastroenterology, Johns Hopkins Medical Institutions Campus, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.gie.2020.12.035","article-title":"ASGE guideline on the role of endoscopy in the management of malignant hilar 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