{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:08:55Z","timestamp":1780056535815,"version":"3.54.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnancy\n                    and leads to serious harm to the mother and the fetus. A variety of lncRNAs play\n                    a key role in GDM. This meta-analysis was performed to explore the potential\n                    value of lncRNAs in GDM diagnosis. Articles correlated with lncRNA and GDM were\n                    screened from Embase, Medline, EBSCO, PubMed, Chinese National Knowledge\n                    Infrastructure, and WanFang databases. Summary receiver operator characteristic\n                    (SROC) was performed to evaluate the pooled area under curve (AUC). Forest plot\n                    was conducted to calculate the sensitivity, specificity, diagnostic likelihood\n                    ratio (LR), diagnostic score, and diagnostic odds ratio (DOR). Deeks\u2019 funnel\n                    plot was utilized to evaluate the publication bias. Eleven articles containing\n                    12 tests (1060 GDM patients and 1066 controls) were included in this\n                    meta-analysis. AUC (0.89, 95%CI=0.86\u20130.92), sensitivity (0.84, 95%CI=0.80\u20130.87),\n                    and specificity (0.81, 95%CI=0.77\u20130.85)of the SROC curve showed a high\n                    diagnostic value of lncRNA for GDM. Positive LR (PLR 4.40, 95%CI=3.45\u20135.60) and\n                    negative LR (NLR 0.20, 95%CI=0.15\u20130.26) results indicated that the diagnosis of\n                    lncRNA for GDM had low clinical utility. Diagnostic score (3.09,\n                    95%CI=2.62\u20133.57) and DOR (22.04, 95%CI=13.68\u201335.51) results suggested lncRNAs\n                    have good discriminative effect on GDM. Heterogeneity was significantly higher,\n                    but not induced by the subgroups. LncRNAs had high diagnostic value and good\n                    discriminative effect for GDM, but the clinical utility was not high. This\n                    meta-analysis study offers a potential target for GDM diagnosis.<\/jats:p>","DOI":"10.1055\/a-2379-1326","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T22:55:01Z","timestamp":1728946501000},"page":"67-74","source":"Crossref","is-referenced-by-count":1,"title":["The Value of lncRNAs as a Biomarker for the Diagnosis of Gestational\n                    Diabetes: A Meta-Analysis"],"prefix":"10.1055","volume":"57","author":[{"given":"Yang","family":"Fan","sequence":"first","affiliation":[{"name":"People\u02bcs Hospital of Ningxia Hui Autonomous Region, Ningxia Medical\n                    University, Ningxia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"first","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou\n                    University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[{"name":"General Practice, Hefei First People\u02bcs Hospital, Hefei,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Tu","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, The General Hospital of Western Theater\n                    Command PLA, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, The General Hospital of Western Theater\n                    Command PLA, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, The General Hospital of Western Theater\n                    Command PLA, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, Wuxi Maternity and Child Health Care\n                    Hospital (Affiliated Women's Hospital of Jiangnan University), Wuxi,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A clinical update on gestational diabetes mellitus","volume":"43","author":"A Sweeting","year":"2022","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e060694","DOI":"10.1136\/bmjopen-2021-060694","article-title":"Incidence and risk factors of gestational diabetes mellitus in Goba town,\n                    Southeast Ethiopia: a prospective cohort study","volume":"12","author":"D 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         miR-517a\/IGF-1 in the placenta of diabetic macrosomia","volume":"29","author":"S Guiyu","year":"2022","journal-title":"Reprod Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/nep.14112","article-title":"Role of lncRNA-MEG8\/miR-296-3p axis in gestational diabetes mellitus","volume":"27","author":"G Bian","year":"2022","journal-title":"Nephrology (Carlton)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.17219\/acem\/121524","article-title":"Expression and function of lncRNA MALAT1 in gestational diabetes mellitus","volume":"29","author":"Y Zhang","year":"2020","journal-title":"Adv Clin Exp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2147\/DMSO.S263942","article-title":"lncRNA SNHG17 is downregulated in gestational diabetes mellitus (GDM) and has\n                    predictive values","volume":"14","author":"J Li","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1159\/000491969","article-title":"Circulating lncRNA serve as fingerprint for gestational diabetes mellitus\n                    associated with risk of macrosomia","volume":"48","author":"J Lu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ijgo.12384","article-title":"Long non-coding RNA MALAT1 expression in patients with gestational diabetes\n                    mellitus","volume":"140","author":"Y Zhang","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.5603\/GP.a2022.0052","article-title":"Plasma Lnc-UCA1\/miR-138 axis as a potential biomarker for gestational diabetes\n                    mellitus and neonatal prognosis","volume":"94","author":"B Leng","year":"2023","journal-title":"Ginekol Pol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.2147\/IJGM.S341106","article-title":"Long Non-coding RNA HOTAIR expression and clinical significance in patients with\n                    gestational diabetes","volume":"14","author":"R Su","year":"2021","journal-title":"Int J Gen Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1159\/000520340","article-title":"LncRNA OIP5-AS1 Signatures as a biomarker of gestational diabetes mellitus and a\n                    regulator on trophoblast cells","volume":"86","author":"Y Li","year":"2021","journal-title":"Gynecol Obstet Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.21037\/cdt-21-110","article-title":"LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus\n                    and its regulatory effect on trophoblast cell via miR-497-5p\/FOXO1 axis","volume":"11","author":"Y Li","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"key":"ref25","first-page":"870","article-title":"The expression level and clinical significance of lncRNA-SNX17 in the serum of\n                    pregnant women with gestational diabetes mellitus","volume":"30","author":"H Cao","year":"2022","journal-title":"Chin J Birth Health Heredity"},{"key":"ref26","first-page":"108","article-title":"Expression and significance of lncRNA-HOTTIP and miR-21 in serum of patients\n                    with gestational diabetes mellitus","volume":"35","author":"D Ma","year":"2022","journal-title":"J Clin Hematol"},{"key":"ref27","first-page":"106","article-title":"Value of expression level of lncRNA-p3134 in diagnosing gestational diabetes\n                    mellitus","volume":"25","author":"F Xie","year":"2021","journal-title":"J Clin Med Pract"},{"key":"ref28","first-page":"96","article-title":"Expression of secreted frizzled related protein 5, long non-coding RNA\n                    transcripts associated with metastasis in human lung adenocarcinoma and\n                    adipokine retinal protein-1 in gestational Chin","volume":"30","author":"J Ju","year":"2021","journal-title":"J Hum Sexual"},{"key":"ref29","first-page":"e56969","article-title":"Assessment of women\u02bcs awareness of the effects of gestational diabetes mellitus\n                    on the mother and fetus in Saudi Arabia: a cross-sectional study","volume":"16","author":"A Gari","year":"2024","journal-title":"Cureus"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2174\/18756212MTA3qNDApy","article-title":"Effects of maternal obesity and gestational diabetes mellitus on the placenta:\n                    current knowledge and targets for therapeutic interventions","volume":"19","author":"S Bedell","year":"2021","journal-title":"Curr Vasc Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e067946","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review\n                    and meta-analysis","volume":"377","author":"W Ye","year":"2022","journal-title":"BMJ"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4149\/gpb_2023019","article-title":"LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the\n                    microRNA-181b-5p\/NDRG2 axis","volume":"42","author":"Y Xu","year":"2023","journal-title":"Gen Physiol Biophys"}],"container-title":["Hormone and Metabolic 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