{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:40:04Z","timestamp":1788543604998,"version":"build-2803163510"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conservative therapy is favored over revascularization for patients with peripheral arterial disease (PAD) and intermittent claudication (IC) owing to the better long-term results. The adjunctive use of intravascular ultrasound (IVUS) significantly improves endovascular therapy. However, data on IVUS and IC is scarce. Therefore, the aim of this investigation was to determine the safety and efficacy of IVUS in patients with IC and to evaluate discrepancies compared to angiography and potential consequences for treatment.<\/jats:p><jats:p>This was a single-center prospective cohort study. Twenty patients with IC and femoropopliteal disease eligible for endovascular therapy were enrolled. Procedural data and discrepancies between IVUS and angiography were recorded.<\/jats:p><jats:p>In total, 30 lesions were treated. IVUS-based measurements yielded substantially higher reference vessel diameters (RVD) and lesion lengths compared to DSA alone (RVD: 5.37 \u00b1 0.71 mm vs. 4.74 \u00b1 0.63 mm, p&lt;.001, lesion length: 62.4 \u00b1 41.4 mm vs. 42.18 \u00b1 30.2 mm, p&lt;.001). In 24 of 30 lesions (80%), a significant discrepancy in RVD (defined as difference &gt;0.5 mm) and lesion length (defined as &gt;20 mm) was determined between IVUS and standard DSA. Subsequently, IVUS assessment led to upsizing in 14 of 30 lesions (47%) and downsizing in 3 of 30 lesions (10%). On average, IVUS led to the selection of considerably larger balloons (5.25 \u00b1 0.62 vs. 4.74 \u00b1 0.63, p&lt;.004) and device length (78.97 \u00b1 44.19 mm vs. 42.18 \u00b1 30.2, p&lt;.001). Serious adverse events did not occur. Technical success was achieved in all cases.<\/jats:p><jats:p>IVUS is safe and provides advantages regarding the evaluation of IC by depicting RVD and lesion length more reliably than standard DSA. More precise assessment of lesions resulted in the use of significantly larger devices.<\/jats:p>","DOI":"10.1055\/a-2379-8857","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T22:54:09Z","timestamp":1725576849000},"page":"682-689","source":"Crossref","is-referenced-by-count":2,"title":["Endovascular therapy in intermittent claudication: Impact of IVUS guidance on treatment decisions"],"prefix":"10.1055","volume":"197","author":[{"given":"Viktor","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Wurzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Augustin","sequence":"additional","affiliation":[{"name":"Department of Interventional and Diagnostic Radiology, Klinikum Bayreuth GmbH, Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Gruschwitz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Wurzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-1620","authenticated-orcid":false,"given":"Jan-Peter","family":"Grunz","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Wisconsin-Madison, Madison, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Knarr","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Wurzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Kickuth","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Wurzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.23736\/S0392-9590.18.03996-2","article-title":"Epidemiology of peripheral artery disease in Europe: VAS Educational Paper","volume":"37","author":"DM Olinic","year":"2018","journal-title":"Int Angiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"FG Fowkes","year":"2013","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2S","DOI":"10.1016\/j.jvs.2014.12.009","article-title":"Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower 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