{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:06:23Z","timestamp":1779231983256,"version":"3.51.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hintergrund Die Riesenzellarteriitis (RZA) erfordert unverz\u00fcgliche Diagnostik und Therapie. Am Universit\u00e4tsklinikum W\u00fcrzburg wurde zur Optimierung der interdisziplin\u00e4ren Zusammenarbeit das Zentrum f\u00fcr Riesenzellarteriitis (ZeRi) gegr\u00fcndet.<\/jats:p>\n                  <jats:p>Ziel der Arbeit Retrospektive Auswertung der 5-Jahres-Daten zur Beurteilung des Stellenwertes der einzelnen angewendeten diagnostischen Methoden, insbesondere der Temporalisbiopsie.<\/jats:p>\n                  <jats:p>Patienten und Methoden Retrospektive Auswertung von 101 Patienten, die zwischen 2017 und 2022 mit Verdacht auf RZA interdisziplin\u00e4r untersucht wurden und eine Biopsie der A.\u00a0temporalis erhielten. Spezifit\u00e4t und Sensitivit\u00e4t von klinischer Symptomatik, BSG, CRP, MRT-Diagnostik, Sonografie und Biopsie der A.\u00a0temporalis wurden analysiert.<\/jats:p>\n                  <jats:p>Ergebnisse Bei 75 von 101 Patienten mit Verdacht auf RZA wurde mithilfe o.\u200ag. Diagnostik die Diagnose RZA gestellt. Die Biopsie hatte definitionsbedingt einen positiv pr\u00e4diktiven Wert von 100% bei einer Spezifit\u00e4t von 84,6%, der negativ pr\u00e4diktive Wert betrug 51,2%. Die Sonografie der A.\u00a0temporalis und die MRT hatten einen positiven pr\u00e4diktiven Wert von \u00fcber 93% bei einer Sensitivit\u00e4t von 62,5% bzw. 76,1%. Die h\u00f6chste Sensitivit\u00e4t hatte die klinische Symptomatik mit 92% bei einer Spezifit\u00e4t von 57,7%. Die BSG und das CRP waren bei den RZA-Patienten signifikant h\u00f6her als bei den Patienten ohne RZA, wobei die Vorhersagekraft der CRP-Werte h\u00f6her war als die der BSG.<\/jats:p>\n                  <jats:p>Diskussion Mit einer gezielten Anamnese sowie der Bestimmung von BSG und CRP k\u00f6nnen die meisten F\u00e4lle von RZA detektiert werden. Die Sonografie und MRT der Kopfschwarte k\u00f6nnen RZA-Verdachtsf\u00e4lle i.\u200ad.\u200aR.\u00a0best\u00e4tigen, sodass eine Biopsie der A.\u00a0temporalis nur noch in Ausnahmef\u00e4llen erforderlich ist.<\/jats:p>","DOI":"10.1055\/a-2381-1884","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T19:17:17Z","timestamp":1728587837000},"page":"608-615","source":"Crossref","is-referenced-by-count":0,"title":["5-Jahres-Daten des interdisziplin\u00e4ren Riesenzellarteriitis-Registers des Universit\u00e4tsklinikums W\u00fcrzburg: Stellenwert der Temporalisbiopsie"],"prefix":"10.1055","volume":"243","author":[{"given":"Carla","family":"Winter","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum W\u00fcrzburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Theuersbacher","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum W\u00fcrzburg, 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