{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:29:44Z","timestamp":1744172984498,"version":"3.40.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Clinical Center","award":["HD 11725 Diabetes in Pregnancy (PPG)"],"award-info":[{"award-number":["HD 11725 Diabetes in Pregnancy (PPG)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>This study aimed to review the Cincinnati PPG's contribution to the understanding and treatment of neonatal hypocalcemia (NHC) in infants of diabetic mothers. This study is a retrospective review of the NIH-funded Program Project Grant (PPG) works related to mineral metabolism in type 1 diabetic pregnant women. The PPG investigators first described the epidemiology and the additional risk factors for NHC, namely prematurity and neonatal asphyxia, but also recognized the independent effect of maternal diabetes mellitus. They explored the link between NHC and maternal\/neonatal hypomagnesemia. They finally conducted a randomized control trial of prevention of NHC by early administration of magnesium sulfate soon after birth to prevent NHC. The PPG in its various phases has allowed to reveal the important role that magnesium plays in the regulation of mineral metabolism in pregnancy and in particular the pregnancy complicated by pregestational diabetes.<\/jats:p>","DOI":"10.1055\/a-2382-7475","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:38:46Z","timestamp":1723160326000},"page":"691-696","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Magnesium Connection: The Cincinnati PPG's Pioneering Work on Mineral Metabolism in Diabetes and Pregnancy"],"prefix":"10.1055","volume":"42","author":[{"given":"Francis B.","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Research Institute, Leumit Health Services, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane C.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Department of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barak","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Sheffer-Mimouni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Research Institute, Leumit Health Services, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menachem","family":"Miodovnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inova Health System, Falls Church, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1542\/peds.45.5.773","article-title":"Neonatal hypocalcemia in low birth weight infants","volume":"45","author":"R C Tsang","year":"1970","journal-title":"Pediatrics"},{"issue":"03","key":"ref2","first-page":"384","article-title":"Hypocalcemia in infants of diabetic mothers. 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