{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:47:05Z","timestamp":1789001225688,"version":"build-2803163510"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Real-world data on the management of patients with primary biliary cholangitis (PBC) are so far scarce in Germany. Therefore, we aimed to establish a nationwide registry and describe the clinical characteristics and therapy of PBC patients.<\/jats:p><jats:p>Three different cohorts defined as ursodeoxycholic acid (UDCA) responders, as inadequate responders according to Paris II criteria, and as newly diagnosed patients were prospectively recruited.<\/jats:p><jats:p>This manuscript includes the baseline data of the project.<\/jats:p><jats:p>In total, 33\/77 (43%) contacted centres (58% of university hospitals, 38% of non-university hospitals, and 24% of private practices) recruited 515 patients including 204 UDCA responders, 221 inadequate responders to UDCA, and 90 newly diagnosed patients.<\/jats:p><jats:p>All patients were treated with UDCA; however, a UDCA dosage below the recommended dosage of 13 mg\/kg\/d was observed in 38.5% of individuals after 12 months of treatment. UDCA dosages were lower in nonacademic compared to academic centres.<\/jats:p><jats:p>Only 75\/219 (38.5%) of inadequate responders to UDCA received a second-line therapy with obeticholic acid (OCA) and\/or bezafibrate (BZF). OCA (13% vs. 4.5%) and BZF (14% vs. 6.5%) were significantly more often prescribed by academic vs. nonacademic centres.<\/jats:p><jats:p>Pruritus (27% vs. 15.5%), fatigue (23% vs. 4.5%), and sicca syndrome (14% vs. 1%) were significantly more often reported by academic centres.<\/jats:p><jats:p>The German PBC registry could be established, which indicates suboptimal therapy in a relevant proportion of patients and shows significant differences between academic and nonacademic centres. Results are fundamental to improving clinical management at different levels of care.<\/jats:p>","DOI":"10.1055\/a-2382-7720","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T23:19:58Z","timestamp":1725405598000},"page":"1931-1942","source":"Crossref","is-referenced-by-count":11,"title":["Sub-optimal therapy of patients with primary biliary cholangitis (PBC) in the real-life stetting of the German PBC cohort"],"prefix":"10.1055","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-4064","authenticated-orcid":false,"given":"Johannes","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Medicine II, University Medical Centre, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Franke","sequence":"additional","affiliation":[{"name":"Clinical Trial Centre of Medical Faculty, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Stein","sequence":"additional","affiliation":[{"name":"Practice of Hepatology Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Bantel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Medicine I, Universit\u00e4tsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Denk","sequence":"additional","affiliation":[{"name":"Department of Medicine II and Transplantation Center, University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-475X","authenticated-orcid":false,"given":"Philipp A.","family":"Reuken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious diseases), Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, Metabolic Liver Research Program, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Naumann","sequence":"additional","affiliation":[{"name":"UBN Private Practice, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00f6ttler","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 6 Gastroenterology, Hepatology, Endocrinology, Hospital Nuremberg, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Goethe University, University Hospital, 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