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We, here, give an overview about the history and the current knowledge of the histology, genetics, and molecular characteristics and pathogenesis of gastric MALT lymphoma. We then focus on how these findings have fundamentally changed its clinical management over the last three decades with consequent deescalating therapeutic strategies.<\/jats:p>","DOI":"10.1055\/a-2382-7820","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T23:05:48Z","timestamp":1727305548000},"page":"1952-1962","source":"Crossref","is-referenced-by-count":2,"title":["From modern pathogenetic insights and molecular understanding to new deescalating therapeutic strategies in gastric MALT-lymphoma"],"prefix":"10.1055","volume":"62","author":[{"given":"Wolfgang","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Gastroenterologische Gemeinschaftspraxis Aschaffenburg, Klinikum Aschaffenburg-Alzenau, Academic Teaching Hospital of the University of W\u00fcrzburg, Aschaffenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Eck","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Klinikum Aschaffenburg-Alzenau, Academic Teaching Hospital of the University of W\u00fcrzburg, Aschaffenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/1097-0142(19920901)70:5<1075::AID-CNCR2820700511>3.0.CO;2-1","article-title":"Malignant lymphoma of the upper gastrointestinal tract. 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