{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:52:07Z","timestamp":1790610727097,"version":"4.1.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The high cardiometabolic risk associated with polycystic ovary syndrome (PCOS)\n                    may be linked to central fat accumulation. This study compared fat distribution\n                    between women with PCOS and controls matched by body mass index. It also sought\n                    to determine if insulin resistance (IR), androgens, or inflammatory markers\n                    correlate with body composition parameters in PCOS patients. In total,\n                    thirty-five women with PCOS and 37 controls, aged 18\u201340 years, were included.\n                    Hormonal\/metabolic profiles, inflammatory biomarkers [tumor necrosis\n                    factor-alpha (TNF-\u03b1 and interleukin-6 (IL-6)], anthropometry (waist\n                    circumference, waist-to-hip ratio, lipid accumulation product [LAP], visceral\n                    adiposity index [VAI]), and body composition assessed through dual-energy X-ray\n                    absorptiometry were assessed. The PCOS group exhibited significantly higher\n                    androgen levels and markers of IR. However, levels of TNF-\u03b1 and IL-6 were\n                    comparable between the groups. Despite having similar total body fat mass (FM),\n                    the PCOS group had excessive central fat, including increased truncal FM and\n                    visceral adipose tissue (VAT). In PCOS, androgens were not associated with body\n                    fat or its distribution. IL-6 was positively correlated with total and truncal\n                    FM, while insulinemia and the homeostatic model assessment for IR were\n                    positively associated with VAT, as well as with total and truncal FM. Although\n                    anthropometric measurements and indices were positively associated with\n                    DXA-derived central FM parameters, our data suggest that LAP is the most\n                    effective tool for assessing central fat deposition and metabolic dysfunction in\n                    the PCOS patients studied herein. Furthermore, in this population, IR, rather\n                    than androgens or proinflammatory cytokines, is more closely associated with\n                    abdominal obesity.<\/jats:p>","DOI":"10.1055\/a-2386-9281","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T23:12:18Z","timestamp":1725405138000},"page":"25-32","source":"Crossref","is-referenced-by-count":12,"title":["Fat Distribution and its Correlation with Insulin Resistance,\n                    Androgen Markers, and Proinflammatory Cytokines in Polycystic Ovary\n                    Syndrome"],"prefix":"10.1055","volume":"57","author":[{"given":"Rebeca Bandeira","family":"de Melo Cavalcante","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Pathophysiology, Rio de Janeiro State University Faculty of Medical Sciences,\n                    Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenora Maria Camarate Silveira Martins","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Endocrinology Department of Internal Medicine, Rio de\n                    Janeiro State University Faculty of Medical Sciences, Rio de Janeiro,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Winter","family":"Tavares","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Pathophysiology, Rio de Janeiro State University Faculty of Medical Sciences,\n                    Rio de Janeiro, Brazil"},{"name":"Endocrinology Department of Internal Medicine, Rio de\n                    Janeiro State University Faculty of Medical Sciences, Rio de Janeiro,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karynne Grutter","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Pathophysiology, Rio de Janeiro State University Faculty of Medical Sciences,\n                    Rio de Janeiro, Brazil"},{"name":"Obesity Unit (SAI-Ob), Multiuser Clinical Research\n                    Center (CePeM), Pedro Ernesto University Hospital, Rio de Janeiro State\n                    University, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Guilherme","family":"Kraemer-Aguiar","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Pathophysiology, Rio de Janeiro State University Faculty of Medical Sciences,\n                    Rio de Janeiro, Brazil"},{"name":"Endocrinology Department of Internal Medicine, Rio de\n                    Janeiro State University Faculty of Medical Sciences, Rio de Janeiro,\n                    Brazil"},{"name":"Obesity Unit (SAI-Ob), Multiuser Clinical Research\n                    Center (CePeM), Pedro Ernesto University Hospital, Rio de Janeiro State\n                    University, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4103\/jhrs.JHRS_95_18","article-title":"The prevalence of olycystic ovary syndrome: a brief systematic review","volume":"13","author":"R Deswal","year":"2020","journal-title":"J Hum Reprod Sci"},{"key":"ref2","first-page":"90","article-title":"Long term health consequences of polycystic ovarian syndrome: a review\n                    analysis","volume":"13","author":"A Daniilidis","year":"2009","journal-title":"Hippokratia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/humrep\/15.4.785","article-title":"Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension\n                    and coronary artery disease in perimenopausal women with a history of the\n                    polycystic ovary syndrome","volume":"15","author":"D Cibula","year":"2000","journal-title":"Hum Reprod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1471-0528.2006.00973.x","article-title":"The central issue? 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