{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:22:31Z","timestamp":1790079751325,"version":"4.0.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Nipro Joint research","award":["23430004"],"award-info":[{"award-number":["23430004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003In the treatment of peripheral nerve injuries with nerve defects, second-generation collagen-based conduits, such as Renerve\u00ae (Nipro, Osaka, Japan), have shown the potential for promoting nerve regeneration. However, there is concern related to the weak material properties. No previous studies have addressed the strength of the bridging model using collagen conduits. This study aimed to investigate the tensile strength and failure patterns in nerve defect models bridged with Renerve\u00ae conduits through biomechanical research.<\/jats:p><jats:p>\n          Methods\u2003Using fresh chicken sciatic nerves, we examined the maximum failure load of four groups: bridging models using Renerve\u00ae with one suture (group A), with two sutures (group B), with three sutures (group C), and end-to-end neurorrhaphy models with two sutures (group N). Each group had eight specimens. We also evaluated failure patterns of the specimens.<\/jats:p><jats:p>\n          Results\u2003Group N showed a significantly higher maximum failure load (0.96\u2009\u00b1\u20090.13\u2009N) compared to groups A (0.23\u2009\u00b1\u20090.06\u2009N, p\u2009&lt;\u20090.0001), B (0.29\u2009\u00b1\u20090.05\u2009N, p\u2009&lt;\u20090.0001), and C (0.40\u2009\u00b1\u20090.10\u2009N, p\u2009&lt;\u20090.0001). Regarding failure patterns, all specimens in group A showed nerve-end dislocation from the conduit. Two specimens in group B and three specimens in group C failed due to circumferential cracks in the conduit. Six specimens in group B and five specimens in group C exhibited cutting out of sutures from the conduit.<\/jats:p><jats:p>\n          Conclusion\u2003This study suggests that the number of sutures in synthetic collagen nerve conduits has little effect on the maximum failure load. To take advantage of its biomaterial benefits, a period of postoperative range of motion restriction may be required.<\/jats:p>","DOI":"10.1055\/a-2387-3282","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T23:12:22Z","timestamp":1723677142000},"page":"383-389","source":"Crossref","is-referenced-by-count":3,"title":["Tensile Strength of Nerve Bridging Models Using Collagen Nerve Conduits"],"prefix":"10.1055","volume":"41","author":[{"given":"Yusuke","family":"Hattori","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"},{"name":"Department of Orthopedic Surgery, Nagoya City University East Medical Center, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5410-2706","authenticated-orcid":false,"given":"Takuya","family":"Usami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Joyo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University East Medical Center, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Permsak","family":"Paholpak","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Hand Surgery, Nagoya Ekisaikai Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1021\/acschemneuro.9b00203","article-title":"Peripheral nerve conduit: materials and structures","volume":"10","author":"S Houshyar","year":"2019","journal-title":"ACS Chem Neurosci"},{"issue":"S 04","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.injury.2008.08.029","article-title":"Artificial nerve tubes and their application for repair of peripheral nerve injury: an update of current concepts","volume":"39","author":"S 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