{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:56:16Z","timestamp":1764244576133,"version":"3.46.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Ein 3 Monate alter Europ\u00e4isch-Kurzhaar-Kater, der auf einem Bauernhof geboren\n                    wurde, wurde aufgrund von wechselnden Lahmheiten, Fieber und Inappetenz\n                    erfolglos mit Meloxicam vorbehandelt. Bei Vorstellung lag eine Lahmheit (Grad\n                    2\/4) der rechten Vordergliedma\u00dfe mit geringgradiger Weichteilschwellung vor. Die\n                    Rektaltemperatur betrug 39,9\u00b0C. Bei einer aufgrund des Verdachts einer\n                    Polyarthritis durchgef\u00fchrten Gelenkpunktion kam es zu einer \u00fcberm\u00e4\u00dfigen Blutung;\n                    eine mittelgradige An\u00e4mie entwickelte sich. Die Gerinnungsdiagnostik ergab eine\n                    isoliert verl\u00e4ngerte aktivierte partielle Thromboplastinzeit (aPTT). Die\n                    Aktivit\u00e4t von Faktor VIII betrug 5% (Referenzbereich: 70\u2013125%), von Faktor IX\n                    55% (80\u2013130%) und von Faktor XII 73% (50\u2013140%).<\/jats:p>\n                  <jats:p>Im Rahmen einer genetischen Untersuchung wurden Exons und angrenzende\n                    Intron-Sequenzen des felinen F8-Gens sequenziert und mit der Referenz\n                    (ENSFCAT00000078256.1) verglichen. W\u00e4hrend in den Exons keine nicht-synonymen\n                    Varianten gefunden wurden, zeigte sich im Intron 19 die Variante\n                    c.6073+2\u2009T&gt;C. Diese Variante f\u00fchrt wahrscheinlich zur Ver\u00e4nderung der\n                    Splei\u00df-Stelle, untypischen Splei\u00dfen und damit zu einer ver\u00e4nderten mRNA f\u00fcr\n                    Faktor VIII.<\/jats:p>\n                  <jats:p>Der Kater wurde symptomatisch behandelt (Metamizol, Buprenorphin, Tranexams\u00e4ure)\n                    und die klinischen Symptome besserten sich. Im Alter von 8 und 18 Monaten wurde\n                    der Kater mittels eines GnRH-Implantats chemisch kastriert, wobei es nach der\n                    zweiten Implantation zu einer geringgradigen Blutung an der Implantationsstelle\n                    kam. Nach inzwischen 3,5 Jahren lebt der Kater nahezu symptomfrei.<\/jats:p>\n                  <jats:p>Die isolierte aPTT-Verl\u00e4ngerung war hinweisend auf einen Faktormangel. Eine\n                    Faktoraktivit\u00e4tsbestimmung f\u00fchrte zur Diagnose H\u00e4mophilie A. Die genetische\n                    Untersuchung f\u00fchrte zur Entdeckung einer Splei\u00df-Variante im F8-Gen.<\/jats:p>","DOI":"10.1055\/a-2404-1427","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T18:30:25Z","timestamp":1729794625000},"page":"314-323","source":"Crossref","is-referenced-by-count":0,"title":["H\u00e4mophilie A bei einem Kater mit wechselnden\n                    Lahmheiten"],"prefix":"10.1055","volume":"52","author":[{"given":"Sabine","family":"Beetz","sequence":"additional","affiliation":[{"name":"Klein- und Heimtierklinik, Fachbereich Veterin\u00e4rmedizin, Freie\n                    Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Weingart","sequence":"additional","affiliation":[{"name":"Klein- und Heimtierklinik, Fachbereich Veterin\u00e4rmedizin, Freie\n                    Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Renner","sequence":"additional","affiliation":[{"name":"Klein- und Heimtierklinik, Fachbereich Veterin\u00e4rmedizin, Freie\n                    Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kehl","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, Bad Kissingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Menzel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Mischke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, Bad Kissingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kohn","sequence":"additional","affiliation":[{"name":"Klein- und Heimtierklinik, Fachbereich Veterin\u00e4rmedizin, Freie\n                    Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Spontaneous thoracolumbar hematomyelia secondary to hemophilia B in a cat","volume":"1","author":"L R Barnard","year":"2015","journal-title":"JFMS Open Rep"},{"key":"ref2","first-page":"413","article-title":"Zur Thrombozytenaggregation bei der Katze","volume":"19","author":"S Hart","year":"1991","journal-title":"Tierarztl Prax"},{"key":"ref3","first-page":"672","article-title":"Factor VIII deficiency in a cat","volume":"10","author":"I B Johnstone","year":"1987","journal-title":"Can Vet J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.2460\/javma.1993.203.12.1702","article-title":"Factor 9 deficiency (haemophilia B) in a familiy of british shorthair cats","volume":"12","author":"L Maggio-Price","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1939-1676.1995.tb01088.x","article-title":"Hemostatic disorders in cats: a retrospective study and review of the\n                    literature","volume":"9","author":"J L Peterson","year":"1995","journal-title":"J Vet Intern Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2460\/javma.1997.211.05.576","article-title":"Factor X deficiency in a cat","volume":"211","author":"J L Gookin","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.5326\/0380549","article-title":"Congenital factor XI deficiency in a domestic shorthair cat","volume":"38","author":"M T Troxel","year":"2002","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/9781119500537.ch90","volume-title":"Hereditary coagulopathies. In: Brooks, Hrsg. Schalm\u2018s veterinary hematology","author":"M B Brooks","year":"2022"},{"volume-title":"Praktische H\u00e4matologie bei Hund und Katze. Vet","year":"2003","author":"R Mischke","key":"ref9"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2460\/javma.245.6.677","article-title":"Clinical outcome after diagnosis of hemophilia A in dogs","volume":"245","author":"M E Aslanian","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cvsm.2013.10.003","article-title":"Pediatric clinical pathology","volume":"44","author":"B von Dehn","year":"2014","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1439-0442.1996.tb00440.x","article-title":"Influence of sample predilution on the sensitivity of prothrombin time in feline\n                    plasma","volume":"43","author":"R Mischke","year":"1996","journal-title":"Zentralbl Veterinarmed A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1439-0442.1995.tb00406.x","article-title":"Messung der Aktivit\u00e4t der Gerinnungsfaktoren VIII:C, IX, XI und XII bei der\n                    Katze","volume":"42","author":"R Mischke","year":"1995","journal-title":"Zentralbl Veterinarmed A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.15256\/joc.2011.1.2","article-title":"Haemophilia and joint disease: pathophysiology, evaluation, and management","volume":"1","author":"K Knobe","year":"2011","journal-title":"J Comorb"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1111\/jth.15444","article-title":"Hemophilic arthropathy: Current knowledge and future perspectives","volume":"19","author":"R Gualtierotti","year":"2021","journal-title":"J Thromb Haemost"},{"key":"ref16","first-page":"621","article-title":"Chronic progressive polyarthritis in a domestic shorthair cat","volume":"56","author":"H Inkpen","year":"2015","journal-title":"Can Vet J"},{"key":"ref17","first-page":"6","article-title":"Lameness, generalised myopathy and myalgia in an adult cat with\n                    toxoplasmosis","author":"D R Butts","year":"2020","journal-title":"JFMS Open Rep"},{"key":"ref18","first-page":"1245","volume-title":"Hematology. In: Couto CG, Nelson RW, eds. Small animal internal medicine","author":"C G Couto","year":"2014"},{"key":"ref19","first-page":"279","article-title":"H\u00e4mophilie A beim Hund: Symptome, Blutgerinnungsanalyse und Behandlung","volume":"109","author":"R Mischke","year":"1996","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"ref20","first-page":"491","volume-title":"Krankheiten des Blutes. In: Lutz H, Kohn B, Forterre F, Hrsg. Krankheiten der\n                    Katze. 6. Aufl","author":"B Kohn","year":"2019"},{"key":"ref21","first-page":"31","volume-title":"Anemia. In: Day M, Kohn B, eds. BSAVA Manual of canine and feline haematology\n                    and transfusion medicine. 2nd ed","author":"J Mills","year":"2012"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1053\/j.tcam.2012.07.004","article-title":"Diagnostic approach to small animal bleeding disorders","volume":"27","author":"J Herring","year":"2012","journal-title":"Top Companion Anim Med"},{"key":"ref23","first-page":"11","article-title":"H\u00e4mophilie in der Hausarztpraxis","author":"F Boehlen","year":"2011","journal-title":"Swiss Med Forum"},{"key":"ref24","first-page":"221","article-title":"Classic hemophilia (hemophilia A) in a family of collies","volume":"19","author":"D M Benn","year":"1978","journal-title":"Can Vet J"},{"key":"ref25","first-page":"438","volume-title":"Inherited haemorrhagic defects. In: Kirk RW, Hrsg. Current veterinary therapy\n                    VI. Small animal practice","author":"W J Dodds","year":"1977"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1055\/s-0038-1623619","article-title":"H\u00e4mophilie A und B beim Hund","volume":"40","author":"R Mischke","year":"2012","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref27","first-page":"12","article-title":"A SINE insertion in F8 gene leads to severe form of hemophilia A in a family of\n                    Rhodesian Ridgebacks","author":"A Kehl","year":"2021","journal-title":"Genes (Basel)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/age.13345","article-title":"A frameshift deletion in F8 associated with hemophilia A in Labrador Retriever\n                    dogs","volume":"54","author":"M K Hyt\u00f6nen","year":"2023","journal-title":"Anim Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint\n                    consensus recommendation of the American College of Medical Genetics and\n                    Genomics and the Association for Molecular Pathology","volume":"17","author":"S Richards","year":"2015","journal-title":"Genet Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.18240\/ijo.2023.10.06","article-title":"A novel pathogenic splicing mutation of RPGR in a Chinese family with X-linked\n                    retinitis pigmentosa verified by minigene splicing assay","volume":"16","author":"H-Q Wang","year":"2023","journal-title":"Int J Ophthalmol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1007\/s10072-022-05893-4","article-title":"A splice altering variant in NDRG1 gene causes Charcot-Marie-Tooth disease, type\n                    4D","volume":"43","author":"P Pravinbabu","year":"2022","journal-title":"Neurol Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1476-4431.2009.00437.x","article-title":"Factor VIII inhibitors complicating treatment of postoperative bleeding in a dog\n                    with hemophilia A","volume":"19","author":"B M O\u2019Kelley","year":"2009","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1177\/1098612X19876728","article-title":"Retrospective evaluation of the indications, safety and effects of fresh frozen\n                    plasma transfusions in 36 cats (2014-2018)","volume":"22","author":"E T Mansi","year":"2020","journal-title":"J Feline Med Surg"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.1002\/9781119500537","volume-title":"ed. Schalm\u2019s veterinary hematology. 7th ed","author":"M B Brooks","year":"2022"},{"key":"ref35","first-page":"855","volume-title":"Treatment of hemostatic defects. In: Brooks MB, ed. Schalm\u2019s veterinary\n                    hematology. 7th ed","author":"R Goggs","year":"2022"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/1098612X211007071","article-title":"2021 ISFM Consensus guidelines on the collection and administration of blood and\n                    blood products in cats","volume":"23","author":"S Taylor","year":"2021","journal-title":"J Feline Med Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1053\/j.tcam.2012.07.006","article-title":"Inherited disorders of hemostasis in dogs and cats","volume":"27","author":"J W Barr","year":"2012","journal-title":"Top Companion Anim Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/rda.12301","article-title":"Suppression of fertility in adult cats","volume":"49","author":"S Goericke-Pesch","year":"2014","journal-title":"Reprod Domest Anim"},{"key":"ref39","first-page":"10","article-title":"Case series: Heinz body formation in 13 multimorbid dogs following metamizole\n                    administration","author":"V Geisen","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/1098612X19849969","article-title":"Evaluation of postoperative pain and toxicological aspects of the use of\n                    dipyrone and tramadol in cats","volume":"22","author":"L G Teixeira","year":"2020","journal-title":"J Feline Med Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5603\/AIT.a2015.0011","article-title":"Tranexamic acid: a clinical review","volume":"47","author":"W Ng","year":"2015","journal-title":"Anaesthesiol Intensive Ther"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/vec.13237","article-title":"Retrospective analysis of the use of tranexamic acid in critically ill dogs and\n                    cats (2018-2019): 266 dogs and 28 cats","volume":"32","author":"M Kelley","year":"2022","journal-title":"J Vet Emerg Crit Care (San Antonio)"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2404-1427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:54:35Z","timestamp":1764244475000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2404-1427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":42,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2024,10,24]]},"published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2404-1427","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}