{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:49:27Z","timestamp":1773092967344,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current standard of care for the definitive surgical treatment of complicative ulcerative colitis is a continence-preserving proctocolectomy with the creation of an ileal pouch anal anastomosis. In addition to structural and functional disorders, pouchitis of the J-pouch is a common phenomenon, typically well responsive to antimicrobial therapy. However, sometimes chronic antibiotic-refractory pouchitis occurs, most often due to not completely understood multifactorial pathomechanisms. While high-quality evidence is available only for anti-integrin therapy, the role of advanced therapy, i.e., cytokine-antibodies or small molecules in the treatment of chronic antibiotic-refractory pouchitis (CARP), is emerging.<\/jats:p><jats:p>This case demonstrates a successful induction treatment of CARP with the novel p19-selective IL-23-targeted antibody mirikizumab.<\/jats:p>","DOI":"10.1055\/a-2404-4518","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T23:05:48Z","timestamp":1727305548000},"page":"269-272","source":"Crossref","is-referenced-by-count":1,"title":["Mirikizumab for the treatment of chronic antibiotic-refractory pouchitis"],"prefix":"10.1055","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-3578","authenticated-orcid":false,"given":"Johannes","family":"Reiner","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie und Endokrinologie, Zentrum f\u00fcr Innere Medizin, Universit\u00e4tsmedizin Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Becker","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tsmedizin Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Huth","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie und Endokrinologie, Zentrum f\u00fcr Innere Medizin, Universit\u00e4tsmedizin Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie und Endokrinologie, Zentrum f\u00fcr Innere Medizin, Universit\u00e4tsmedizin Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Witte","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Allgemein-, Viszeral-, Thorax-, Gef\u00e4\u00df- und Transplantationschirurgie, Universit\u00e4tsmedizin Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/BF02234320","article-title":"Long-term follow-up after ileoanal pouch procedure: algorithm for diagnosis, classification, and management of pouchitis","volume":"44","author":"UA Heuschen","year":"2001","journal-title":"Diseases of the colon and rectum"},{"issue":"08","key":"ref2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1055\/a-2060-0935","article-title":"Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 6.1) \u2013 Februar 2023 \u2013 AWMF-Registriernummer: 021\u2013009","volume":"61","author":"T Kucharzik","year":"2023","journal-title":"Zeitschrift fur Gastroenterologie"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00423-009-0479-7","article-title":"Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis","volume":"395","author":"C Leowardi","year":"2010","journal-title":"Langenbeck\u2019s archives of surgery"},{"issue":"01","key":"ref4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.amjsurg.2022.01.018","article-title":"Ileal Pouch Anal Anastomosis (IPAA) for colitis; 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