{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T23:10:11Z","timestamp":1747091411174,"version":"3.40.5"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Numerous surgical fields have embraced computer-aided design and computer-aided manufacturing (CAD\/CAM), including plastic and reconstructive surgery. However, most of the literature and clinical use pertains to reconstruction of the head and neck. Herein, we provide a case series and systematic review of the literature, documenting the use of CAD\/CAM in facilitating complex microvascular free tissue transfer for reconstructions involving the extremities, pelvis, and spine (EPS).<\/jats:p><jats:p>\n          Methods\u2003This study consisted of two components: a case series and a systematic review of the literature. For the case series, the senior author's cases that included CAD\/CAM to assist microvascular free tissue transfer reconstructions of the EPS were included. For the systematic review, all PubMed-, Scopus-, and Google Scholar\u2013indexed studies describing the use of CAD\/CAM to facilitate free tissue transfer in the EPS were identified and included using PRSMA guidelines.<\/jats:p><jats:p>\n          Results\u2003The case series identified 10 patients who received CAD\/CAM-assisted microvascular reconstruction. Our systematic review identified 15 articles, representing 124 patients and 133 CAD\/CAM-assisted free tissue transfers. Most authors believed that CAD\/CAM facilitated a more efficient operation by shifting much of the intraoperative planning to the preoperative phase, ultimately translating to a shorter and more accurate surgery with improved function and cosmesis.<\/jats:p><jats:p>\n          Conclusion\u2003CAD\/CAM can be used to facilitate microvascular reconstruction of the EPS. Our cases series and systematic review suggest that CAD\/CAM for EPS surgery may improve outcomes.<\/jats:p>","DOI":"10.1055\/a-2404-7819","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T23:49:45Z","timestamp":1724802585000},"page":"432-442","source":"Crossref","is-referenced-by-count":0,"title":["Computer-Aided Design and Manufacturing to Facilitate Microvascular Free Tissue Transfer in Extremity, Pelvic, and Spinal Reconstructions"],"prefix":"10.1055","volume":"41","author":[{"given":"Alec D.","family":"Simoni","sequence":"additional","affiliation":[{"name":"The University of Arizona College of Medicine, Phoenix, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin E.","family":"Bird","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick P.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence D.","family":"Rhines","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander F.","family":"Mericli","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0002-9416(76)90226-8","article-title":"Superior repositioning of the maxilla: stability and soft tissue osseous 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