{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:45:14Z","timestamp":1785156314337,"version":"3.55.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>This study aimed to evaluate the most effective regimen to raise hemoglobin (Hb) by comparing alternate-day dosing of iron to daily dosing in pregnant women with iron deficiency anemia. Women with Hb\u2009&lt;\u200911.0\u2009g\/dL and ferritin \u2264 25 \u00b5g\/L between 120\/7 and 340\/7 weeks' gestation were recruited. A total of 88 patients were randomized using block randomization with 1:1 allocation to receive either 1 tablet of 325\u2009mg ferrous sulfate on consecutive days or 2 tablets every other day. The primary outcome, the change in Hb after 6 weeks of treatment was assessed using an analysis of covariance to adjust for baseline level. Secondary outcomes included change in ferritin, hepcidin, side effects, and compliance. Patients completed a questionnaire to assess for adverse symptoms and adherence was monitored by installing a pill reminder app on smartphones of patients. A total of 88 patients were consented. The daily iron group had a greater proportion of nulliparous women (40 vs. 7%). Most patients (98%) had mild anemia (Hb: 9\u201310.9\u2009g\/dL) at recruitment, with a median gestational age of 28.1 weeks (interquartile range [IQR]: 25.6, 30.9) and median duration of treatment of 42 days (IQR: 35, 45). At 6 weeks, the daily iron group had a mean increase in Hb of 0.8\u2009\u00b1\u20090.9\u2009g\/dL, whereas the alternate-day iron group had a mean increase of 0.5\u2009\u00b1\u20091.0\u2009g\/dL (baseline adjusted difference of means: \u22120.3 [95% confidence interval: \u22120.7, 0.1], p\u2009=\u20090.15). Frequency of adverse effects attributable to iron were similar between groups. Patient self-reported compliance to treatment was also similar between groups. Among those that used the app, compliance was higher among the daily group compared with the alternate daily group (median: 95.5% [IQR: 75, 100] vs. 85% [IQR: 40, 92]), although this difference was not statistically significant (p\u2009=\u20090.07). This trial suggests that there are no significant differences between alternate-day iron supplementation and daily iron supplementation for treating iron deficiency anemia.<\/jats:p>","DOI":"10.1055\/a-2405-1381","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T23:35:36Z","timestamp":1724974536000},"page":"699-707","source":"Crossref","is-referenced-by-count":6,"title":["Daily versus Alternate-Day Iron Supplementation for Pregnant Women with Iron Deficiency Anemia: A Randomized Controlled Trial"],"prefix":"10.1055","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct03562143","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-8581","authenticated-orcid":false,"given":"Melissa Chu","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Northshore University Hospital, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binny","family":"Khandakar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Sinai West, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaak","family":"Heon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Sinai West, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Hussain","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-209X","authenticated-orcid":false,"given":"Elianna","family":"Kaplowitz","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Overbey","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Brustman","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Rosenn","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Jersey City Medical Center, Jersey City, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2105\/AJPH.92.2.288","article-title":"Effects of iron supplementation on maternal hematologic status in pregnancy","volume":"92","author":"N L Sloan","year":"2002","journal-title":"Am J Public Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"630519","DOI":"10.1155\/2012\/630519","article-title":"Iron deficiency anaemia in pregnancy and postpartum: pathophysiology and effect of oral versus intravenous iron therapy","volume":"2012","author":"A A Khalafallah","year":"2012","journal-title":"J 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