{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T23:10:07Z","timestamp":1748387407176,"version":"3.41.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003We aimed to investigate the accuracy of clinical staging without the routine use of positron emission tomography\/computed tomography (PET\/CT) in patients with cIA1 and cIA2 non-small-cell lung cancer (NSCLC) scheduled for segmentectomy.<\/jats:p><jats:p>\n          Methods\u2003A total of 305 consecutive segmentectomies were retrospectively analyzed. Overall survival was calculated using the Kaplan\u2013Meier method. Logistic regression was performed to investigate factors independently associated with pathologic upstaging.<\/jats:p><jats:p>\n          Results\u2003The Union for International Cancer Control (UICC) upstaging was found in 86 patients (28%). Upstaged patients had longer operative times (146\u2009\u00b1\u200946 vs. 131\u2009\u00b1\u200944\u2009minutes, p\u2009=\u20090.009), a higher number of lymph node resection (17\u2009\u00b1\u200910 vs. 13\u2009\u00b1\u20098, p\u2009=\u20090.001), and a higher rate of L1 involvement (34 vs. 16%, p\u2009&lt;\u20090.001) than nonupstaged patients. N1 was found in 10 patients (3%) and N2 in 13 patients (4%). Nodal positive patients had longer operation times (154\u2009\u00b1\u200950 vs. 133\u2009\u00b1\u200944\u2009minutes, p\u2009=\u20090.031) and higher rates of R1 (9 vs. 1%, p\u2009=\u20090.006) and L1 (39 vs. 20%, p\u2009&lt;\u20090.026) than patients without nodal involvement. The 3- and 5-year overall survival rates for nonupstaged and upstaged patients were 85 and 67% and 67 and 54%, respectively (p\u2009=\u20090.040). In logistic regression, L1 involvement (odds ratio [OR]: 2.394, p\u2009=\u20090.005) and the number of dissected lymph nodes (OR: 1.037, p\u2009=\u20090.016) were independently associated with upstaging. Patients who received PET as part of clinical staging did not have a significantly lower nodal upstaging.<\/jats:p><jats:p>\n          Conclusion\u2003Selective use of PET\/CT based on the results of CT may be a viable option for patients with proven or suspected NSCLC up to 2\u2009cm in size.<\/jats:p>","DOI":"10.1055\/a-2405-2603","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T23:42:36Z","timestamp":1724974956000},"page":"317-324","source":"Crossref","is-referenced-by-count":0,"title":["Staging of Early-Stage Lung Cancer without Routine PET in Candidates for Segmentectomy"],"prefix":"10.1055","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-5394","authenticated-orcid":false,"given":"Alberto","family":"Lopez-Pastorini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, St. Hildegardis Krankenhaus, K\u00f6ln, Nordrhein-Westfalen, Germany"},{"name":"Faculty of Medicine, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Tatli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Cologne, K\u00f6ln, Nordrhein-Westfalen, German"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"von Bargen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Faltenberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Beling","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Cologne, K\u00f6ln, Nordrhein-Westfalen, German"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Koryllos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Witten\/Herdecke University, Witten, Germany"},{"name":"Department of Thoracic Surgery, Florence-Nightingale-Krankenhaus, D\u00fcsseldorf, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Galetin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Witten\/Herdecke University, Witten, Germany"},{"name":"Department of Thoracic Surgery, Florence-Nightingale-Krankenhaus, D\u00fcsseldorf, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Stoelben","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, St. Hildegardis Krankenhaus, K\u00f6ln, Nordrhein-Westfalen, Germany"},{"name":"Faculty of Medicine, University of Cologne, K\u00f6ln, Nordrhein-Westfalen, German"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.lungcan.2004.11.006","article-title":"Poor correspondence between clinical and pathologic staging in stage 1 non-small cell lung cancer: results from CALGB 9761, a prospective trial","volume":"48","author":"J D'Cunha","year":"2005","journal-title":"Lung Cancer"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1056\/NEJMoa2212083","article-title":"Lobar or sublobar resection for peripheral stage IA non-small-cell lung cancer","volume":"388","author":"N Altorki","year":"2023","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","article-title":"Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802\/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial","volume":"399","author":"H Saji","year":"2022","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lungcan.2022.08.013","article-title":"Survival outcomes in a prospective randomized multicenter phase III trial comparing patients undergoing anatomical segmentectomy versus standard lobectomy for non-small cell lung cancer up to 2\u2009cm","volume":"172","author":"G Stamatis","year":"2022","journal-title":"Lung Cancer"},{"volume-title":"2019 Exceptional Surveillance of Lung Cancer: Diagnosis and Management (NICE guideline NG122)","year":"2019","author":"National Institute for Health and Care Excellence (NICE)","key":"ref5"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1016\/j.jacr.2019.02.008","article-title":"ACR Appropriateness Criteria\u00ae noninvasive clinical staging of primary lung cancer","volume":"16","author":"P M de Groot","year":"2019","journal-title":"J Am Coll Radiol"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.annonc.2021.08.1994","article-title":"Early and locally advanced non-small-cell lung cancer: an update of the ESMO Clinical Practice Guidelines focusing on diagnosis, staging, systemic and local therapy","volume":"32","author":"J Remon","year":"2021","journal-title":"Ann Oncol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1055\/a-2029-0134","article-title":"Pr\u00e4vention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms","volume":"77","author":"W Sch\u00fctte","year":"2023","journal-title":"Pneumologie"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for staging non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"G A Silvestri","year":"2013","journal-title":"Chest"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.athoracsur.2016.06.071","article-title":"The quality of staging non-small cell lung cancer in the Netherlands: data from the Dutch lung surgery audit","volume":"102","author":"D J Heineman","year":"2016","journal-title":"Ann Thorac Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.chest.2018.10.020","article-title":"The accuracy of clinical staging of stage I-IIIa non-small cell lung cancer: an analysis based on individual participant data","volume":"155","author":"N Navani","year":"2019","journal-title":"Chest"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.athoracsur.2008.01.018","article-title":"Does positron emission tomography prevent nontherapeutic pulmonary resections for clinical stage IA lung cancer?","volume":"85","author":"B D Kozower","year":"2008","journal-title":"Ann Thorac Surg"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1200\/JCO.2005.02.4695","article-title":"Traditional versus up-front [18F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study","volume":"24","author":"G J Herder","year":"2006","journal-title":"J Clin Oncol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/ejcts\/ezr272","article-title":"False-negative rate after positron emission tomography\/computer tomography scan for mediastinal staging in cI stage non-small-cell lung cancer","volume":"42","author":"A G\u00f3mez-Caro","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"issue":"03","key":"ref15","first-page":"100035","article-title":"Numbers and stations: impact of examined lymph node on precise staging and survival of radiologically pure-solid NSCLC: a multi-institutional study","volume":"1","author":"D Chen","year":"2020","journal-title":"JTO Clin Res Rep"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1200\/JCO.2016.67.5140","article-title":"Impact of examined lymph node count on precise staging and long-term survival of resected non-small-cell lung cancer: a population study of the US SEER database and a Chinese multi-institutional registry","volume":"35","author":"W Liang","year":"2017","journal-title":"J Clin Oncol"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1097\/JTO.0b013e31822a35c3","article-title":"Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer","volume":"6","author":"H Saji","year":"2011","journal-title":"J Thorac Oncol"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.21037\/tlcr-20-1024","article-title":"A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer","volume":"10","author":"Z Zhu","year":"2021","journal-title":"Transl Lung Cancer Res"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.athoracsur.2014.11.052","article-title":"Visceral pleural invasion remains a size-independent prognostic factor in stage I non-small cell lung cancer","volume":"99","author":"H Huang","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jtcvs.2004.11.021","article-title":"Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer","volume":"130","author":"K Shimizu","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1148\/radiol.2015151120","article-title":"Pleural tags on CT scans to predict visceral pleural invasion of non-small cell lung cancer that does not abut the pleura","volume":"279","author":"J S Hsu","year":"2016","journal-title":"Radiology"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.21037\/jtd.2016.05.90","article-title":"Visceral pleural invasion in lung adenocarcinoma \u22643\u2009cm with ground-glass opacity: a clinical, pathological and radiological study","volume":"8","author":"L L Zhao","year":"2016","journal-title":"J Thorac Dis"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.athoracsur.2023.06.020","article-title":"Segmentectomy vs lobectomy for early non-small cell lung cancer with visceral pleural invasion","volume":"117","author":"C Mathey-Andrews","year":"2024","journal-title":"Ann Thorac 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