{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:41:35Z","timestamp":1792748495226,"version":"4.5.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Bleeding from gastric varices is life-threatening, with significant rebleeding risk despite standard cyanoacrylate glue injection therapy. Our aim was to evaluate the efficacy and safety of endoscopic ultrasonography (EUS)-guided coil embolization with cyanoacrylate injection (Coil+CYA) compared with EUS-guided cyanoacrylate injection alone (CYA) for the treatment of gastric varices.<\/jats:p>\n                  <jats:p>Methods The study was conducted at a tertiary referral center in India, using a single-blinded, prospective, and parallel-group randomized design. A total of 50 patients were randomly assigned (1 : 1) to Coil+CYA or CYA. The primary outcome was clinical success (i.e. variceal obliteration). Secondary outcomes involved technical success, gastric variceal recurrence during follow-up, rebleeding episodes, reintervention, and survival.<\/jats:p>\n                  <jats:p>Results Post-intervention, gastric variceal obliteration assessed by EUS was higher in the Coil+CYA group (100% vs. 92.3%; P = 0.49), with both groups achieving 100% technical success. Rebleeding episodes during 0\u201312 and 12\u201324 weeks were comparable in the two groups. At 12 weeks, on EUS, variceal reappearance was less common in the Coil+CYA group (12.5% vs. 19.2%; P = 0.70). Significantly fewer reinterventions were needed in the Coil+CYA group (20.8% vs. 53.8%; P = 0.03). The time to reintervention was significantly longer in the Coil+CYA group (P = 0.01), and the survival time was also longer (P = 0.04).<\/jats:p>\n                  <jats:p>Conclusions EUS-guided coil embolization with cyanoacrylate injection achieved superior clinical success, reducing the need for reintervention and resulting in improved survival compared with cyanoacrylate injection alone.<\/jats:p>","DOI":"10.1055\/a-2408-6905","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T18:55:02Z","timestamp":1726685702000},"page":"107-115","source":"Crossref","is-referenced-by-count":30,"title":["Endoscopic ultrasonography-guided coil embolization and cyanoacrylate injection versus cyanoacrylate injection alone for gastric varices: a randomized comparative study"],"prefix":"10.1055","volume":"57","clinical-trial-number":[{"clinical-trial-number":"ctri\/2022\/08\/045100","registry":"10.18810\/clinical-trial-registry-india"}],"author":[{"given":"Ashok","family":"Jhajharia","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Yadav","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Singh","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachis","family":"Ashdhir","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Nijhawan","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1590\/s0004-28032009000100020","article-title":"Endoscopic follow-up of cyanoacrylate obliteration of gastric varices","volume":"46","author":"FP Martins","year":"2009","journal-title":"Arq Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1055\/s-2007-1018288","article-title":"N-butyl-2-cyanoacrylate: a supplement to endoscopic sclerotherapy","volume":"19","author":"N 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Binmoeller","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.gie.2013.05.009","article-title":"EUS-guided coil versus cyanoacrylate therapy for the treatment of gastric varices: a multicenter study (with videos)","volume":"78","author":"R Romero-Castro","year":"2013","journal-title":"Gastrointest Endosc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/hep.1840160607","article-title":"Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients","volume":"16","author":"SK Sarin","year":"1992","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII \u2013 Renewing consensus in portal hypertension","volume":"76","author":"R De Franchis","year":"2022","journal-title":"J 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Levy","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/s0004-2803.201900000-08","article-title":"Safety and efficacy of EUS-guided coil plus cyanoacrylate versus conventional cyanoacrylate technique in the treatment of gastric varices: A randomized controlled trial","volume":"56","author":"MR de Almeida L\u00f4bo","year":"2019","journal-title":"Arq Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1055\/a-1123-9054","article-title":"Endoscopic ultrasonography-guided deployment of embolization coils and cyanoacrylate injection in gastric varices versus coiling alone: a randomized trial","volume":"52","author":"C 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