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The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, \u03b1-pinene, and \u03b2-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G\n          protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.<\/jats:p>","DOI":"10.1055\/a-2409-3735","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T19:48:26Z","timestamp":1725392906000},"page":"1005-1014","source":"Crossref","is-referenced-by-count":7,"title":["Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function"],"prefix":"10.1055","volume":"90","author":[{"given":"Andr\u00e9 Nogueira","family":"Cardeal dos Santos","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Edn\u00e9sio","family":"da Cruz Freire","sequence":"additional","affiliation":[{"name":"Biochemistry and Gene Expression Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Ferreira","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Walber","family":"Ferreira-da-Silva","sequence":"additional","affiliation":[{"name":"Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo Ribeiro Hon\u00f3rio","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Neuroscience and Translational Medicine Laboratory, Christus University Center, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Henrique","family":"Leal Cardoso","sequence":"additional","affiliation":[{"name":"Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrelina Noronha Coelho","family":"de Souza","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/27697061.2023.2245435","article-title":"Nutritional aspects, chemistry profile, extraction techniques of lemongrass essential oil and it\u02bcs physiological benefits","volume":"43","author":"K Adhikary","year":"2024","journal-title":"J Am Nutr Assoc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"155227","DOI":"10.1016\/j.phymed.2023.155227","article-title":"Essential oil from fructus Alpinia zerumbet ameliorates atherosclerosis by activating PPAR\u03b3-LXR\u03b1-ABCA1\/G1 signaling pathway","volume":"123","author":"S Q Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/bit.28590","article-title":"Plant-based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview","volume":"121","author":"Y Jamir","year":"2024","journal-title":"Biotechnol Bioeng"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1590\/S0102-695X2009000200009","article-title":"Antioxidant capacity and biological activity of essential oil and methanol extract of Hyptis crenata Pohl ex Benth","volume":"19","author":"M M Rebelo","year":"2009","journal-title":"Rev bras farmacogn"},{"key":"ref5","first-page":"1387","article-title":"Chemical composition and biological activities of essential oil from Hyptis crenata growing in the Brazilian cerrado","volume":"7","author":"I MP Violante","year":"2012","journal-title":"Nat Prod Commun"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cbi.2014.02.013","article-title":"Synergistic antiproliferative and anticholesterogenic effects of linalool, 1, 8-cineole, and simvastatin on human cell lines","volume":"214","author":"B Rodenak Kladniew","year":"2014","journal-title":"Chem Biol Interact"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"117337","DOI":"10.1016\/j.jep.2023.117337","article-title":"Essential oil from Ligusticum chuanxiong Hort. 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