{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:08:08Z","timestamp":1785190088772,"version":"3.55.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this exploration of Curcuma longa Linn., commonly known as turmeric,\n                    renowned for its therapeutic history, our study focuses on the bioactive\n                    compound curcumin. We established and validated an HPLC method for precise\n                    curcumin quantification, complemented by an examination of total phenolic and\n                    flavonoid content, as well as antioxidant capabilities in a methanolic extract\n                    from C. longa rhizomes obtained through a methanol-based Soxhlet\n                    extraction. The HPLC analysis utilized a C18 column with a mobile phase of\n                    70:30\u2009V\/V Acetonitrile (ACN) to Water (with 1% Glacial Acetic Acid) under an\n                    isocratic elution at 1\u2009mL\/min, detection at 420\u2009nm, and a reference standard.\n                    The method exhibited notable accuracy, precision, and reproducibility.\n                    Antioxidant potential, assessed through DPPH, nitric oxide, and hydroxyl radical\n                    scavenging assays, unveiled significant total phenol and total flavonoid\n                    quantities, highlighting C. longa\u2019s potent antioxidant capacity. The\n                    study demonstrated a correlation between antioxidant activities and phenolic and\n                    flavonoid concentrations, reinforcing the robustness of our method. In\n                    conclusion, this method offers an effective means of quantifying curcumin within\n                        C. longa rhizomes and holds promise as a valuable tool for\n                    maintaining quality control in the production of this botanical material.<\/jats:p>","DOI":"10.1055\/a-2413-3740","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T22:52:14Z","timestamp":1727391134000},"page":"475-482","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the HPLC Profiling and Antioxidant Potency in Methanolic\n                    Extracts of Curcuma longa L. Rhizomes"],"prefix":"10.1055","volume":"74","author":[{"given":"Babita","family":"Shukla","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow, India"},{"name":"Harsha Institute of Pharmacy, Lucknow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref1","first-page":"s671\u2013685","article-title":"A comprehensive review on Curcuma longa Linn.: Phytochemical,\n                    pharmacological, and molecular study","volume":"11","author":"K Ashraf","year":"2017","journal-title":"International Journal of Green Pharmacy (IJGP)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: A review of its effects on human health","volume":"6","author":"S J Hewlings","year":"2017","journal-title":"Foods"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43094-021-00330-3","article-title":"Validated high-performance thin-layer chromatographic analysis of curcumin in\n                    the methanolic fraction of Curcuma longa L. rhizomes","volume":"7","author":"P Kushwaha","year":"2021","journal-title":"Future Journal of Pharmaceutical Sciences"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3390\/nu13051519","article-title":"Curcuma Longa, the \u201cGolden Spice\u201d to Counteract Neuroinflammaging and\n                    Cognitive Decline\u2014What Have We Learned and What Needs to Be Done","volume":"13","author":"A Berry","year":"2021","journal-title":"Nutrients"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1002\/ptr.7224","article-title":"A review of therapeutic potentials of turmeric (Curcuma longa) and its\n                    active constituent, curcumin, on inflammatory disorders, pain, and their related\n                    patents","volume":"35","author":"B M Razavi","year":"2021","journal-title":"Phytotherapy Research"},{"key":"ref6","first-page":"2021","article-title":"Pharmacological activities of Curcuma longa: A review. Eur","volume":"8","author":"N A Bhatt","year":"2021","journal-title":"J Mol Clin Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.15406\/ppij.2020.08.00307","article-title":"Development and evaluation of herbal cream containing Curcumin from Curcuma\n                        longa","volume":"8","author":"M M Al-Busaid","year":"2020","journal-title":"Pharm Pharmacol Int J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1515\/acs-2016-0022","article-title":"Antioxidant properties of curcuminoids isolated from Curcuma longa L","volume":"9","author":"S Mosovska","year":"2016","journal-title":"Acta Chimica Slovaca"},{"key":"ref10","first-page":"176","article-title":"Screening of total phenolic and flavonoid content in conventional and\n                    non-conventional species of curcuma","volume":"2","author":"R Sahu","year":"2013","journal-title":"Journal of Pharmacognosy and phytochemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.22456\/2527-2616.74150","article-title":"Quantification of atropine in leaves of Atropa belladonna: development\n                    and validation of method by high-performance liquid chromatography (HPLC)","volume":"1","author":"M Koetz","year":"2017","journal-title":"Drug Anal Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jaim.2018.02.135","article-title":"RP-HPLC analysis of methanol extract of Viscum articulatum","volume":"11","author":"M Nag","year":"2020","journal-title":"J Ayurveda Integr Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"986","DOI":"10.5740\/jaoacint.18-0378","article-title":"High-performance liquid chromatography (HPLC) as a tool for standardization of\n                    complex herbal drugs","volume":"102","author":"R Govindarajan","year":"2019","journal-title":"J AOAC Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2306\/scienceasia1513-1874.2017.43.169","article-title":"HPLC methods for quality control of Moringa oleifera extract using\n                    isothiocyanates and astragalin as bioactive markers","volume":"43","author":"J Engsuwan","year":"2017","journal-title":"Sci Asia"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"8471785","DOI":"10.1155\/2017\/8471785","article-title":"Antioxidant properties of popular turmeric (Curcuma longa) varieties from\n                    Bangladesh","volume":"2017","author":"E M Tanvir","year":"2017","journal-title":"Journal of food quality"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/a-2019-4985","article-title":"Development and Validation of HPLC Method for Quantification of Plumbagin in\n                        Plumbago Zeylanica L. 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Using HPLC-MS\/MS and Molecular\n                    Networking","volume":"13","author":"R Budhathoki","year":"2023","journal-title":"Metabolites"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.chroma.2006.01.103","article-title":"Use of liquid chromatography-electrospray ionization tandem mass spectrometry to\n                    identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome","volume":"1111","author":"H Jiang","year":"2006","journal-title":"J Chromatogr A"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"10288","DOI":"10.1038\/s41598-022-13882-y","article-title":"Metabolomics-based profiling for quality assessment and revealing the impact of\n                    drying of Turmeric (Curcuma longa L.)","volume":"12","author":"M A Salem","year":"2022","journal-title":"Sci Rep"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2413-3740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:58:50Z","timestamp":1730825930000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2413-3740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":28,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2024,10,29]]},"published-print":{"date-parts":[[2024,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2413-3740","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]}}}