{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:38:32Z","timestamp":1773643112141,"version":"3.50.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surgical treatment of colorectal cancer carries a risk for venous thromboembolism (VTE). We investigated changes in coagulation and fibrinolysis and the VTE incidence within 30 days in patients undergoing open cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\u2009+\u2009HIPEC) for peritoneal metastases from colorectal cancer and minimally invasive surgery (MIS) for localized rectal cancer.<\/jats:p><jats:p>This cohort study included 45 CRS\u2009+\u2009HIPEC and 45 MIS patients. Blood samples were obtained preoperatively, at the end of surgery, and postoperative day (POD) 1, 3 to 4, and 5 to 7. Systematic ultrasonographic screening for VTE was performed between POD 3 and 7. Computed tomography scan was performed if complications were suspected. The primary endpoint was the difference in mean change (\u0394) with [95% confidence intervals] from preoperative to end of surgery in prothrombin fragment 1\u2009+\u20092 (F1\u2009+\u20092) levels. Secondary endpoints were the difference in mean change in biomarkers of coagulation and fibrinolysis from preoperative to POD 5 to 7 and the VTE incidence.<\/jats:p><jats:p>F1\u2009+\u20092 levels increased from preoperative to the end of surgery in both groups. The mean increase from preoperative to end of surgery in F1\u2009+\u20092 levels was significantly greater in CRS\u2009+\u2009HIPEC patients than MIS patients: \u03941,322 [1,040:1,604] pmol\/L, p\u2009&lt;\u20090.01. The VTE incidence was significantly higher after CRS\u2009+\u2009HIPEC than MIS (24 vs. 5%, p\u2009=\u20090.01).<\/jats:p><jats:p>F1\u2009+\u20092 levels were increased after both procedures, but to a far greater extent following CRS\u2009+\u2009HIPEC. The VTE incidence within 30 days was significantly higher in patients treated with CRS\u2009+\u2009HIPEC than in MIS patients.<\/jats:p>","DOI":"10.1055\/a-2413-4989","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:55:09Z","timestamp":1726095309000},"page":"460-469","source":"Crossref","is-referenced-by-count":2,"title":["Elevated Thrombin Generation and Venous Thromboembolism Incidence in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Compared with Minimally Invasive Rectal Surgery"],"prefix":"10.1055","volume":"125","author":[{"given":"Mikkel","family":"Lundbech","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas E.","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene H.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Surgery, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Brandsborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Anesthesiology South, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Radiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"issue":"151","key":"ref1","doi-asserted-by":"crossref","first-page":"180119","DOI":"10.1183\/16000617.0119-2018","article-title":"Cancer-associated thrombosis: the when, how and why","volume":"28","author":"C J Fernandes","year":"2019","journal-title":"Eur Respir Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"100739","DOI":"10.1016\/j.lanepe.2023.100739","article-title":"Impact of venous thromboembolism on the mortality in patients with cancer: a population-based cohort study","volume":"34","author":"H T 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