{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:39:28Z","timestamp":1753738768169,"version":"3.37.3"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beter Keten Collaboration"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Tissue acquisition is required for diagnosis of subepithelial lesions (SELs). However, obtaining adequate tissue remains challenging. This study investigated an EUS-guided technique using a forceps to create a channel and take multiple biopsies from the center of the lesion, therefore called endoscopic ultrasound-guided keyhole biopsy (EUS-KB).<\/jats:p><jats:p>\n            Patients and methods A retrospective cohort study was conducted in 56 patients with SELs in the upper gastrointestinal tract who were scheduled to undergo EUS-KB. The primary aim was to assess diagnostic yield, defined as the percentage of procedures where EUS-KB resulted in a definitive histopathological diagnosis. Furthermore, factors influencing diagnostic yield were investigated. Additional outcomes included technical success and adverse events.<\/jats:p><jats:p>\n            Results Technical success was achieved in 55 of 60 biopsies (91.7%). EUS-KB provided a diagnosis in 44 of 55 biopsies (80.0%), histology mostly showing gastrointestinal stromal tumor or leiomyoma. The diagnostic yield was not significantly influenced by the size or location of the SEL. Adverse events occurred in one patient (1.7%).<\/jats:p><jats:p>\n            Conclusions EUS-KB is a feasible and safe technique for obtaining a classifying diagnosis for SELs in the upper gastrointestinal tract. It could offer an alternative diagnostic modality, especially in lesions smaller than 20 mm.<\/jats:p>","DOI":"10.1055\/a-2417-0580","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T23:49:09Z","timestamp":1729036149000},"page":"E1183-E1189","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of EUS-guided keyhole biopsies in diagnosing subepithelial lesions of the upper gastrointestinal tract"],"prefix":"10.1055","volume":"12","author":[{"given":"Sen","family":"Verhoeve","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6606-9324","authenticated-orcid":false,"given":"Cynthia","family":"Verloop","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeska","family":"Terpstra","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Centre Haaglanden, Den Haag, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydi","family":"Van Driel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Perk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medisch Centrum Haaglanden, Den Haag, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieke","family":"Hol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","article-title":"Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States","volume":"3","author":"A Dasari","year":"2017","journal-title":"JAMA Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.gie.2017.02.022","article-title":"The role of endoscopy in subepithelial lesions of the GI tract","volume":"85","author":"AL Faulx","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1055\/s-0043-109021","article-title":"Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - 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