{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:37:38Z","timestamp":1791401858156,"version":"4.3.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) is common in hospitalized preterm neonates. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a promising noninvasive AKI biomarker. However, normal values of uNGAL in preterm neonates without AKI are poorly characterized. The objective of this study was to evaluate the current literature to determine normal uNGAL values for preterm neonates without AKI.<\/jats:p>\n                  <jats:p>Systematic review and meta-analysis of all articles published before November 2021 evaluating uNGAL values in preterm neonates without AKI.<\/jats:p>\n                  <jats:p>Of 1,607 studies evaluated for eligibility, 11 were included in the final meta-analysis (210 males, 202 females). uNGAL values were higher in the preterm neonates &lt;29 weeks and ranged between 20.7 and 782.65\u2009ng\/mL. Meta mean estimates of gestational age (GA), birthweight, and neutrophil gelatinase-associated lipocalin were 29.4 weeks (95% confidence interval [CI]: 28.8\u201330.0), 1,241\u2009g (95% CI: 1,111\u20131,372), and 148.9\u2009ng\/mL (95% CI: 48\u2013231), respectively.<\/jats:p>\n                  <jats:p>In limited studies, a wide range of uNGAL values in preterm neonates without AKI are reported. Future studies should identify normal uNGAL values in preterm neonates using larger cohorts by GA and birthweight.<\/jats:p>","DOI":"10.1055\/a-2417-4087","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T19:19:51Z","timestamp":1729624791000},"page":"683-688","source":"Crossref","is-referenced-by-count":10,"title":["Urinary Neutrophil Gelatinase-Associated Lipocalin Values in Preterm Neonates: A Systematic Review and Meta-analysis"],"prefix":"10.1055","volume":"42","author":[{"given":"Tahagod","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Pediatric, Nationwide Children's Hospital, Columbus, Ohio"},{"name":"The Kidney and Urinary Tract Center, Department of Pediatric, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Alexander","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brielle","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Klamer","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center, Department of Pediatric, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Gehred","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-8950","authenticated-orcid":false,"given":"Michelle C.","family":"Starr","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Slagle","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Riley Children's Hospital, Indiana University, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Krawczeski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-3269","authenticated-orcid":false,"given":"Matthew W.","family":"Harer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Wisconsin-Madison, Madison, 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A pilot study","volume":"29","author":"K Sarafidis","year":"2014","journal-title":"Pediatr Nephrol"},{"issue":"06","key":"ref31","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00467-016-3572-5","article-title":"Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine","volume":"32","author":"S Y Shin","year":"2017","journal-title":"Pediatr Nephrol"},{"issue":"02","key":"ref32","first-page":"167","article-title":"Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury in preterm infants","volume":"31","author":"Y Tabel","year":"2014","journal-title":"Am J Perinatol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2417-4087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T18:58:39Z","timestamp":1741287519000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2417-4087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":30,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,3,6]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2417-4087","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]}}}