{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:26:13Z","timestamp":1765423573092,"version":"3.30.1"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die equine granulozyt\u00e4re Anaplasmose (EGA) ist eine zecken\u00fcbertragene\n                    Infektionserkrankung und wird durch den Erreger Anaplasma (A.)\n                        phagocytophilum ausgel\u00f6st. Als Vektoren gelten Zecken des sogenannten\n                        Ixodes (I.) ricinus\/I. persulcatus-Komplexes in\n                    Zentral-, Nord-, West- und Osteuropa, in Deutschland \u00fcberwiegend der Gemeine\n                    Holzbock, I. ricinus. Die Fr\u00fchjahrs- und Sommermonate, insbesondere April\n                    bis Juli, stellen die Hochphase der Aktivit\u00e4t von I. ricinus in\n                    Zentraleuropa dar. Aufgrund der Ver\u00e4nderung klimatischer Bedingungen besteht\n                    mittlerweile ganzj\u00e4hrig das Risiko einer Zeckenexposition und damit auch einer\n                    Infektion mit A. phagocytophilum. Der beschriebene klinische Fall\n                    unterstreicht die saisonale Hochphase des Infektionsrisikos mit Vorstellung des\n                    Pferdes im Juni. Die klinische Symptomatik ist mit Fieber h\u00e4ufig unspezifisch\n                    und eine Thrombozytopenie ist der bedeutendste h\u00e4matologische Befund. Zur\n                    Diagnosestellung einer Infektion bzw. eines Erregerkontaktes sind direkte und\n                    indirekte Nachweisverfahren verf\u00fcgbar. Eine positive PCR best\u00e4tigt wie im\n                    dargestellten Fall eine akute Infektion, positive Antik\u00f6rperspiegel sprechen f\u00fcr\n                    einen Erregerkontakt in der (j\u00fcngeren) Vergangenheit. Einschlussk\u00f6rperchen,\n                    sogenannte Morulae, k\u00f6nnen schnell und kosteng\u00fcnstig in Ausstrichen aus dem\n                    peripheren Blut nachgewiesen werden und finden sich bevorzugt in neutrophilen\n                    Granulozyten, seltener in eosinophilen Granulozyten. Die Mikroskopie weist\n                    jedoch eine geringere Sensitivit\u00e4t im Vergleich zur PCR-Diagnostik auf. Bei dem\n                    beschriebenen Pferd gelang der Nachweis von Morulae im EDTA-Blut trotz positiver\n                    PCR nicht. Intrazellul\u00e4r wirksame Antibiotika wie z.\u2009B. Oxytetracyclin und\/oder\n                    Doxycyclin gelten als Therapie der Wahl und f\u00fchren wie im beschriebenen Fall\n                    meist zu einer schnellen klinischen Besserung an EGA erkrankter Pferde. Eine\n                    Therapiekontrolle mittels PCR wird 5\u20138\u2009Tage nach Abschluss der Behandlung\n                    empfohlen, um eine Elimination des Erregers zu best\u00e4tigen. Ob bzw. wie lange\n                    Antik\u00f6rper gegen A. phagocytophilum m\u00f6glicherweise protektiv gegen\u00fcber\n                    einer erneuten Infektion sein k\u00f6nnten, ist bisher unbekannt. In der Humanmedizin\n                    wird A. phagocytophilum in der n\u00f6rdlichen Hemisph\u00e4re als \u201eemerging human\n                    pathogen\u201c mit steigender klinischer Bedeutung eingestuft.<\/jats:p>","DOI":"10.1055\/a-2418-6540","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T23:47:47Z","timestamp":1733356067000},"page":"352-360","source":"Crossref","is-referenced-by-count":1,"title":["Die granulozyt\u00e4re Anaplasmose des Pferdes: ein Fallbericht und die\n                    epidemiologische Situation mit Fokus auf Deutschland"],"prefix":"10.1055","volume":"52","author":[{"given":"Carla Wiebke","family":"Axt","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Springer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Parasitologie, Zentrum f\u00fcr Infektionsmedizin, Stiftung\n                    Tier\u00e4rztliche Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Besse","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Dr. Arno Besse, Lebach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten J.","family":"Naucke","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Strube","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Parasitologie, Zentrum f\u00fcr Infektionsmedizin, Stiftung\n                    Tier\u00e4rztliche Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. 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