{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:32:15Z","timestamp":1770424335613,"version":"3.49.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Psoriasis is a chronic skin condition that is associated with\n                    persistent inflammation and skin lesions. Topical therapy has been a promising\n                    approach to the alleviation of psoriasis through the application of\n                    anti-inflammatory agents. Phosphatidylserine (PS) administration has shown\n                    anti-inflammatory effects in the trials. Consequently, the objective of this\n                    study was to evaluate the effects of topical PS on the potential improvement of\n                    an imiquimod (IMQ)-induced psoriasis model. Additionally, cyclosporine A was\n                    utilized as a comparative anti-psoriatic agent in our study.<\/jats:p><jats:p>\n          Methods The psoriasis model was established by topically applying IMQ to\n                    the dorsal skin of mice once daily for five consecutive days. The efficacy of\n                    topical PS was assessed using the Psoriasis Area and Severity Index (PASI) score\n                    to evaluate skin lesions. Subsequently, the skin samples were analyzed using\n                    Baker\u2019s scoring system, Masson\u2019s trichrome staining, immunohistochemistry, and\n                    real-time PCR analysis.<\/jats:p><jats:p>\n          Results IMQ-induced plaque-type psoriasis resulted in a significant\n                    increase (P&lt;0.05) in dermal thickness, hyperkeratosis, PASI score, and\n                    inflammatory cytokines at the lesion site. The topical PS and cyclosporine A\n                    significantly (P&lt;0.05) reduced PASI score and dermal thickness, while\n                    also alleviating erythema and scaling when compared to untreated mice.\n                    Furthermore, biomolecular assessments revealed that PS significantly\n                        (P&lt;0.05) inhibited the gene expression of IL-17, IL-23, and TNF-\u03b1\n                    cytokines in the IMQ-induced lesions.<\/jats:p><jats:p>\n          Conclusion Topical PS may pointedly alleviate psoriasis through the\n                    inhibition of inflammation. The beneficial effects of the PS recommend further\n                    investigation in both experimental and clinical studies in the control of skin\n                    psoriasis.\n                <\/jats:p>","DOI":"10.1055\/a-2419-9616","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T23:38:42Z","timestamp":1729035522000},"page":"12-20","source":"Crossref","is-referenced-by-count":3,"title":["Phosphatidylserine Topically Attenuates Imiquimod-induced Psoriasis\n                    Through In\ufb02ammation Inhibition in Mice"],"prefix":"10.1055","volume":"75","author":[{"given":"Bahareh Farasati","family":"Far","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran."},{"name":"Department of Chemistry, Iran University of Science and Technology,\n                    Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partow Mirzaee","family":"Saffari","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh Mohammad","family":"Jafari","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Division of Research and Development, Pharmin USA, LLC, San Jose, CA,\n                    United States of America."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Partoazar","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/jdv.17354","article-title":"Clinical and trichoscopic features in various forms of scalp psoriasis","volume":"35","author":"F Bruni","year":"2021","journal-title":"Journal of the European Academy of Dermatology and\n                    Venereology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/biomedicines9020171","article-title":"Cutaneous squamous cell carcinoma: From pathophysiology to novel therapeutic\n                    approaches","volume":"9","author":"L Fania","year":"2021","journal-title":"Biomedicines"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/1346-8138.15913","article-title":"Pathophysiology of psoriasis: a review","volume":"48","author":"K Yamanaka","year":"2021","journal-title":"The 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phosphatidylserine","volume":"6","author":"X He","year":"2021","journal-title":"Signal transduction and targeted therapy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"103902","DOI":"10.1016\/j.jddst.2022.103902","article-title":"A novel formulation of cyclosporine A\/phosphatidylserine-containing liposome\n                    using remote loading method: Potential product for immunosuppressive\n                    effects","volume":"77","author":"S A Nazeri","year":"2022","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"117861","DOI":"10.1016\/j.lfs.2020.117861","article-title":"Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and\n                    reduce neuroinflammation in streptozotocin-induced Alzheimer's disease\n                    model","volume":"255","author":"P M Saffari","year":"2020","journal-title":"Life 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Effects","volume":"13","author":"Z Valizadeh","year":"2021","journal-title":"Basic & Clinical Cancer Research"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2419-9616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T23:43:34Z","timestamp":1735602214000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2419-9616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":38,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,12,30]]},"published-print":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2419-9616","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}