{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:43:48Z","timestamp":1766731428993,"version":"3.38.0"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento\n                        Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["305231\/2022-7, INCT-SC 406020\/2022-1"],"award-info":[{"award-number":["305231\/2022-7, INCT-SC 406020\/2022-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do\n                        Estado de S\u00e3o Paulo","award":["17\/17728-8, 23\/00229-0, 23\/06469-2"],"award-info":[{"award-number":["17\/17728-8, 23\/00229-0, 23\/06469-2"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de\n                        Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES\/STINT 88887.724090\/2022-00"],"award-info":[{"award-number":["CAPES\/STINT 88887.724090\/2022-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mitochondrial protein NAD(P)+ transhydrogenase (NNT) has been\n                    implicated in the metabolic derangements observed in obesity. Mice with the\n                    C57BL\/6J genetic background bear a spontaneous mutation in the Nnt gene\n                    and are known to exhibit increased susceptibility to diet-induced metabolic\n                    disorders. Most of the studies on NNT in the context of diet-induced obesity\n                    have compared C57BL\/6J mice with other mouse strains, where differences in\n                    genetic background can serve as confounding factors. Moreover, these studies\n                    have predominantly employed a high-fat diet (HFD) consisting of approximately\n                    60% of calories from fat, which may not accurately mimic real-world fat-rich\n                    diets. In this study, we sought to examine the role of NNT in diet-induced\n                    hypothalamic inflammation and metabolic syndrome by using a congenic mice model\n                    lacking NNT, along with a HFD providing approximately 45% of calories from fat.\n                    Our findings indicate that mice lacking NNT were more protected from HFD-induced\n                    weight gain but presented a worse performance on glucose tolerance test, albeit\n                    not in insulin tolerance test. Interestingly, the brown adipose tissue of\n                    HFD-fed Nnt\n          +\/+ mice presented a greater mass and a higher\n                    whole-tissue ex-vivo oxygen consumption rate. Also, HFD increased the expression\n                    of the inflammatory markers Il1\u03b2, Tlr4 and Iba1 in the\n                    hypothalamus of Nnt\n          \u2013\/\u2013 mice. In conclusion, our study\n                    highlights the importance of NNT in the context of diet-induced obesity and\n                    metabolic syndrome, indicating its contribution to mitigate hypothalamic\n                    inflammation and suggesting its role in the brown adipose tissue increased\n                    mass.<\/jats:p>","DOI":"10.1055\/a-2420-6549","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T23:33:06Z","timestamp":1730417586000},"page":"199-207","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Mitochondrial NAD(P)\u2009+\u2009 Transhydrogenase\n                    (NNT) on Hypothalamic Inflammation and Metabolic Dysfunction Induced by a\n                    High-Fat Diet in Mice"],"prefix":"10.1055","volume":"57","author":[{"given":"Giovanna Leite","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka Francislaine","family":"Dias Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Dalla Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane Maria","family":"Zanesco","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities\n                    Research Center, State University of Campinas (UNICAMP), Campinas,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Reymond","family":"Simoes","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities\n                    Research Center, State University of Campinas (UNICAMP), Campinas,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio","family":"Rog\u00e9rio","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Masselli Rodrigues","family":"Demolin","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center for Biological Investigation on\n                    Laboratory Animals Science, State University of Campinas (UNICAMP), Campinas,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Daniele Carvalho","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edcio Augusto","family":"Velloso","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities\n                    Research Center, State University of Campinas (UNICAMP), Campinas,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-8807","authenticated-orcid":false,"given":"Annelise","family":"Francisco","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lunds\n                    Universitet, Lund, Sweden"},{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Frig\u00e9rio","family":"Castilho","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of Campinas\n                    (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic diet\u2013induced obesity and diabetes in\n                    mice","volume":"57","author":"P D Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.18632\/aging.100738","article-title":"High-fat diet induced obesity primes inflammation in adipose tissue prior to\n                    liver in C57BL\/6j mice","volume":"7","author":"R A van der 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