{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:26Z","timestamp":1787004866944,"version":"build-2736575974"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultrasound Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose\u2002A 4-step lung ultrasound (LUS) score has been previously used to quantify lung density. We compared 2 versions of this scoring system for distinguishing severe from moderate loss of aeration in ARDS: coalescence-based score (cLUS) vs. quantitative-based score (qLUS \u2013 &gt;50% pleura occupied by artefacts).<\/jats:p>\n                  <jats:p>Materials and Methods\u2002 We compared qLUS and cLUS to lung density measured by quantitative CT scan in 12 standard thoracic regions. A simplified approach (1 scan per region) was compared to an extensive one (regional score computed as the mean of all relevant intercostal space scores).<\/jats:p>\n                  <jats:p>Results\u2002 We examined 13 conditions in 7 ARDS patients (7 at PEEP 5, 6 at PEEP 15 cmH2O-156 regions, 398 clips). Switching from cLUS to qLUS resulted in a change in interpretation in 117 clips (29.4%, 1-point reduction) and in 41.7% of the regions (64 decreases (range 0.2\u20131), 1 increase (0.2 points)). Regional qLUS showed very strong correlation with lung density (rs=0.85), higher than cLUS (rs=0.79; p=0.010). The agreement with CT classification in well aerated, poorly aerated, and not aerated tissue was moderate for cLUS (agreement 65.4%; Cohen\u2019s K coefficient 0.475 (95%CI 0.391\u20130.547); p&lt;0.0001) and substantial for qLUS (agreement 81.4%; Cohen\u2019s K coefficient 0.701 (95%CI 0.653\u20130.765), p&lt;0.0001). The agreement between single spot and extensive approaches was almost perfect (cLUS: agreement 89.1%, Cohen\u2019s kappa coefficient 0.840 (95%CI 0.811\u20130.911), p&lt;0.0001; qLUS: agreement 86.5%, Cohen\u2019s kappa coefficient 0.819 (95%CI 0.761\u20130.848),\n                              p&lt;0.0001).<\/jats:p>\n                  <jats:p>Conclusion\u2002 A LUS score based on the percentage of occupied pleura performs better than a coalescence-based approach for quantifying lung density. A simplified approach performs as well as an extensive one.<\/jats:p>","DOI":"10.1055\/a-2421-8709","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T19:34:56Z","timestamp":1729539296000},"source":"Crossref","is-referenced-by-count":13,"special_numbering":"S","title":["Lung ultrasound score for the assessment of lung aeration in ARDS patients: comparison of two approaches"],"prefix":"10.1055","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-8599","authenticated-orcid":false,"given":"Silvia","family":"Mongodi","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care, San Matteo Hospital, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Chiumello","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Milan, Milano, Italy"},{"name":"Anaesthesia and Intensive Care, San Paolo University Hospital, Milano, Italy"},{"name":"Coordinated Research Center on Respiratory Failure, University of Milan, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mojoli","sequence":"additional","affiliation":[{"name":"Anesthesiology, Intensive Care and Pain Medicine, San Matteo Hospital, Pavia, Italy"},{"name":"Anesthesiology and Intensive Care, San Matteo Hospital, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.ultrasmedbio.2012.03.001","article-title":"Ex vivo lung sonography: morphologic-ultrasound relationship","volume":"38","author":"G Soldati","year":"2012","journal-title":"Ultrasound Med Biol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/ALN.0000000000003757","article-title":"Quantitative Lung Ultrasound: Technical Aspects and Clinical 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