{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:07:51Z","timestamp":1740175671323,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultrasound Int Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002 To detect sonographic abnormalities of the supratentorial\n                    structures of the brain \u2013 future cavum septum pellucidum, cavum velum\n                    interpositum, third ventricle, ganglionic eminence and thalamus\/hypothalamus \u2013\n                    in fetuses with a crown-rump length of 45\u201384 mm in high-risk pregnancies.<\/jats:p><jats:p>\n          Materials and Methods\u2002 This study presents the retrospective analysis of\n                    transvaginally recorded 3D volumes of the fetal brain of 64 fetuses whose\n                    mothers consulted our ambulatory department for fetomaternal medicine for\n                    organic and\/or genetic changes of their fetuses at GW 12\u201314. For this study we\n                    selected fetuses with 3D volume blocks of the fetal brain at best sonographic\n                    quality enabling detailed analysis and measurement of the supratentorial brain\n                    structures to correlate the results with the results of genetic analysis,\n                    ultrasound controls in later weeks of pregnancy, and fetal outcome.<\/jats:p><jats:p>\n          Results\u2002 Of 44 fetuses with genetic changes and 20 fetuses with syndromic\n                    changes, structural brain changes were found in 27 fetuses, analyzed by\n                    correlating the brain structures with the recently published structures of the\n                    brain at gestational week 12-14 in early pregnancy, presenting new details of\n                    early pathological brain development \u2013 migration disorders, milder variants of\n                    holoprosencephaly (lobar, MIH), corpus callosum agenesis, for the first time in\n                    early pregnancy.<\/jats:p><jats:p>\n          Conclusion\u2002 Supratentorial defects of the brain can be detected and\n                    analyzed in GW 12\u201314 in detail by direct analysis of sonopathology and\n                    visualization of pathological measurements using transvaginal 3D sonography in\n                    high quality.<\/jats:p>","DOI":"10.1055\/a-2422-8443","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T23:49:48Z","timestamp":1734392988000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Detailed Analysis of Fetal Malformations of the Supratentorial\n                    Structures of the Brain in High-Risk Pregnancies at 12\u201314 Gestational Weeks by\n                    Transvaginal 3D Ultrasound Examination"],"prefix":"10.1055","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-724X","authenticated-orcid":false,"given":"Reinhard","family":"Altmann","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Scharnreitner","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Enengl","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Stelzl","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oppelt","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstretrics and Gyn.\n                    Endocrinology, Kepler University Hospital, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1055\/a-1683-6141","article-title":"Visualization of the Third Ventricle, the Future Cavum Septi Pellucidi, and the\n                    Cavum Veli Interpositi at 11+3 to 13+6 Gestational Weeks on 3D Transvaginal\n                    Ultrasound Including Normative Data","volume":"44","author":"R Altmann","year":"2023","journal-title":"Ultraschall in Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00429-023-02679-y","article-title":"Development of the prosencephalic structures, ganglionic eminence, basal ganglia\n                    and thalamus at 11+3 to 13+6 gestational weeks on 3D transvaginal ultrasound\n                    including normative data","volume":"228","author":"R Altmann","year":"2023","journal-title":"Brain Struct 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