{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:20:45Z","timestamp":1791991245928,"version":"4.4.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Although small hypervascular tumors are suspected to be pancreatic neuroendocrine tumors (p-NENs), their diagnosis and treatment are challenging. This study evaluated the usefulness of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for diagnosis of small p-NENs.<\/jats:p><jats:p>\n            Methods All p-NEN lesions that underwent EUS-TA at our hospital between April 2018 and December 2023 were retrospectively analyzed. The diagnostic sensitivity of EUS-TA and the concordance rate of grading with EUS-TA and surgical specimens were examined. The lesions were grouped by size.<\/jats:p><jats:p>\n            Results The diagnostic sensitivity of EUS-TA was analyzed for 82 lesions, of which 44 were compared with postoperative specimens for grading. The definitive diagnosis was neuroendocrine tumor (NET) in 75 lesions, neuroendocrine carcinoma in five lesions, and mixed neuroendocrine non-neuroendocrine neoplasm in two lesions. Thirty tumors were \u226410 mm, 30 were 10 to 20 mm, and 22 were &gt;20 mm, and the diagnostic sensitivities were 96.7%, 96.7%, and 90.9%, respectively. Concordance rates for grading were 94.4%, 82.4%, and 77.8% for tumors \u226410 mm, 10 to 20 mm, and \u226520 mm, respectively, with Cohen\u2019s kappa coefficients of 0.64, 0.48, and 0.40, respectively.<\/jats:p><jats:p>\n            Conclusions EUS-TA showed adequate diagnostic sensitivity and grading agreement for p-NENs of all sizes, allowing for determination of appropriate treatment.<\/jats:p>","DOI":"10.1055\/a-2422-9363","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T23:23:47Z","timestamp":1728343427000},"page":"E1379-E1385","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms"],"prefix":"10.1055","volume":"12","author":[{"given":"Hiromune","family":"Katsuda","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-859X","authenticated-orcid":false,"given":"Masanori","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Ito","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Krimura","sequence":"additional","affiliation":[{"name":"Pathology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1158\/1055-9965.EPI-05-0120","article-title":"Differences in survival by histologic type of pancreatic cancer","volume":"14","author":"MD Fesinmeyer","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref2","first-page":"343","volume-title":"Neuroendocrine neoplasms","author":"AJ Gill","year":"2019"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000443172","article-title":"ENETS consensus guidelines for high-grade gastroenteropancreatic neuroendocrine tumors and neuroendocrine carcinomas","volume":"103","author":"R Garcia-Carbonero","year":"2016","journal-title":"Neuroendocrinology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.21037\/gs-21-564","article-title":"Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm","volume":"10","author":"F Wang","year":"2021","journal-title":"Gland Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000443171","article-title":"ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors","volume":"103","author":"M Falconi","year":"2016","journal-title":"Neuroendocrinology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \u201ccarcinoid\u201d: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"JC Yao","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1677\/ERC-07-0221","article-title":"Pancreatic endocrine neoplasms: epidemiology and prognosis of pancreatic endocrine tumors","volume":"15","author":"TR Halfdanarson","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/cncr.29099","article-title":"Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes","volume":"121","author":"J Hallet","year":"2015","journal-title":"Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1097\/MPA.0000000000000861","article-title":"Regional metastatic behavior of nonfunctional pancreatic neuroendocrine tumors: impact of lymph node positivity on survival","volume":"46","author":"Z Jutric","year":"2017","journal-title":"Pancreas"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12876-021-01685-w","article-title":"Development and validation of a simple-to-use nomogram to predict liver metastasis in patients with pancreatic neuroendocrine neoplasms: a large cohort study","volume":"21","author":"M Pan","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1245\/s10434-014-3769-4","article-title":"Impact of extent of surgery on survival in patients with small non-functional pancreatic neuroendocrine tumors in the United States","volume":"21","author":"L Gratian","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"ref12","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"RV Lloyd","year":"2017"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.surg.2022.08.022","article-title":"A novel tool to predict nodal metastasis in small pancreatic neuroendocrine tumors: A multicenter study","volume":"172","author":"AA Javed","year":"2022","journal-title":"Surgery"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4194","DOI":"10.3748\/wjg.v27.i26.4194","article-title":"Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses, subepithelial lesions, and lymph nodes","volume":"27","author":"I Levine","year":"2021","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"E1393","DOI":"10.1055\/a-0967-4684","article-title":"Endoscopic ultrasound-guided fine-needle aspiration vs fine-needle biopsy for the diagnosis of pancreatic neuroendocrine tumors","volume":"7","author":"LH Eusebi","year":"2019","journal-title":"Endosc Int Open"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.4103\/eus.eus_51_17","article-title":"Evaluation of the SharkCore needle for EUS-guided core biopsy of pancreatic neuroendocrine tumors","volume":"7","author":"BL Witt","year":"2018","journal-title":"Endosc Ultrasound"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1159\/000499172","article-title":"Pancreatic neuroendocrine tumours: the role of endoscopic ultrasound biopsy in diagnosis and grading based on the WHO 2017 classification","volume":"37","author":"M Di Leo","year":"2019","journal-title":"Dig Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.pan.2020.08.023","article-title":"Histological diagnosis and grading of pancreatic neuroendocrine tumor by endoscopic ultrasound-guided fine needle biopsy using a 25-gauge needle with a core trap: A multicenter prospective trial","volume":"20","author":"K Kamata","year":"2020","journal-title":"Pancreatology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00535-016-1164-6","article-title":"Diagnostic performance and factors influencing the accuracy of EUS-FNA of pancreatic neuroendocrine neoplasms","volume":"51","author":"S Hijioka","year":"2016","journal-title":"J Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3390\/diagnostics11020316","article-title":"Role of endoscopic ultrasound in the diagnosis of pancreatic neuroendocrine neoplasms","volume":"11","author":"T Ishii","year":"2021","journal-title":"Diagnostics"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.3109\/00365521.2014.934909","article-title":"The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification","volume":"49","author":"J Unno","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3109\/00365521.2015.1083050","article-title":"Efficacy of endoscopic ultrasonography and endoscopic ultrasonography-guided fine-needle aspiration for the diagnosis and grading of pancreatic neuroendocrine tumors","volume":"51","author":"N Fujimori","year":"2016","journal-title":"Scand J Gastroenterol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/jso.26931","article-title":"Surgery or active surveillance for pNETs < 2 cm: preliminary results from a single center Brazilian cohort","volume":"126","author":"DASM Arra","year":"2022","journal-title":"J Surg Oncol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.surg.2022.04.013","article-title":"Sporadic nonfunctional pancreatic neuroendocrine tumors: risk of lymph node metastases and aggressiveness according to tumor size: a multicenter international study","volume":"172","author":"J Perinel","year":"2022","journal-title":"Surgery"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2422-9363.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:41:07Z","timestamp":1732840867000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2422-9363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,7]]},"published-print":{"date-parts":[[2024,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2422-9363","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10,7]]},"published":{"date-parts":[[2024,10,7]]}}}