{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T05:34:19Z","timestamp":1736919259143,"version":"3.33.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ein 54-j\u00e4hriger Mann stellte sich aufgrund seit etwa 2 Jahren zunehmenden Arthralgien und Schwellungen der Metakarpophalangeal-Gelenke (MCP) II und III vor. Zus\u00e4tzlich klagte er \u00fcber Morgensteifigkeit und Arthralgien in beiden Knien und F\u00fc\u00dfen.<\/jats:p><jats:p>Rheumatologisch zeigten sich Druckschmerzen an den MCP-Gelenken II und III sowie an den proximalen Interphalangeal-Gelenken II und III ohne sichtbare Schwellungen. R\u00f6ntgenaufnahmen der H\u00e4nde wiesen symmetrische Arthrosen der MCP-Gelenke I\u2013III auf. Die Arthrosonografie ergab symmetrische osteophyt\u00e4re Ausziehungen ohne entz\u00fcndliche Zeichen. Laborchemisch waren Ferritin (1436\u00b5g\/l), Eisen (252\u00b5g\/dl) und die Transferrin-S\u00e4ttigung (79%) erh\u00f6ht. Eine homozygote C282Y-Mutation wurde genetisch nachgewiesen, und die FibroScan-Elastografie ergab eine fortgeschrittene Fibrose.<\/jats:p><jats:p>H\u00e4mochromatose-assoziierte Arthropathie.<\/jats:p><jats:p>Einleitung einer symptomorientierten Analgesie mit Metamizol. Station\u00e4r zus\u00e4tzlich physiotherapeutische und ergotherapeutische Behandlungen. Die weitere Therapie erfolgt durch hepatologische Spezialisten eines universit\u00e4ren Zentrums, der Verlauf bleibt abzuwarten.<\/jats:p><jats:p>Ein symmetrischer Befall der MCP-Gelenke II und III sollte an das Vorliegen einer H\u00e4mochromatose denken lassen.<\/jats:p>","DOI":"10.1055\/a-2422-9683","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:19:21Z","timestamp":1736900361000},"page":"101-105","source":"Crossref","is-referenced-by-count":0,"title":["Arthropathie als erste Manifestation einer undiagnostizierten H\u00e4mochromatose: ein Fallbericht zu einem ungew\u00f6hnlichen Verlauf"],"prefix":"10.1055","volume":"150","author":[{"given":"Hoxha","family":"Besjana","sequence":"additional","affiliation":[{"name":"RZ Rheumazentrum Rheinland-Pfalz GmbH, Bad Kreuznach, Deutschland,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikums des Saarlandes, Homburg, Deutschland. Universit\u00e4t des Saarlandes, Saarbr\u00fccken, Deutschland,"},{"name":"Uniklinikum des Saarlandes, Homburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Triantafyllias","sequence":"additional","affiliation":[{"name":"RZ Rheumazentrum Rheinland-Pfalz GmbH, Bad Kreuznach, Deutschland,"},{"name":"Johannes Gutenberg Universit\u00e4tsmedizin Mainz, GERMANY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.jhep.2022.03.033","article-title":"Electronic address eee, European Association for the Study of the L. 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