{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:01:38Z","timestamp":1787756498130,"version":"build-2784847793"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to compare the effectiveness of oral short-acting (SA) nifedipine with intravenous (IV) labetalol for the treatment of postpartum (PP) severe hypertension.<\/jats:p><jats:p>We conducted a retrospective cohort study of women who delivered at a tertiary care facility between January and December 2018, had not previously received antihypertensive medication, and required treatment for PP severe hypertension defined as systolic blood pressure (SBP) \u2265 160\u2009mm Hg and\/or diastolic blood pressure (DBP) \u2265110\u2009mm Hg. Exposure groups were defined by the receipt of either oral SA nifedipine or IV labetalol. The primary outcome was time (minutes) to BP control (SBP\u2009&lt;\u2009160\u2009mm Hg and DBP &lt;110\u2009mm Hg). Secondary outcomes included number of doses required to achieve BP control, crossover to the alternative medication, and recurrence of severe range BP after the achievement of BP control. t-Tests and Wilcoxon\u2013Mann\u2013Whitney tests were used to analyze continuous variables and chi-square tests or Fisher's exact tests were used to analyze categorical variables. Multivariable linear regression models were conducted for the primary outcome, controlling for potential confounders in a sequential fashion across three models. A Kaplan\u2013Meier plot was also created.<\/jats:p><jats:p>Of the 99 women included, 74 received oral SA nifedipine and 25 received IV labetalol. There was no significant difference in minutes to initial BP control between groups (30.5\u2009minutes [interquartile range, IQR: 20.0\u201345.0] vs. 25.0\u2009minutes [IQR: 14.0\u201350.0]; p\u2009=\u20090.82) or in the rate of recurrent severe BP. However, patients who received nifedipine required fewer doses to achieve control (p\u2009&lt;\u20090.01) and did not require crossover (0 vs. 12%, p\u2009=\u20090.01).<\/jats:p><jats:p>Both oral SA nifedipine and IV labetalol are effective options for treating PP severe hypertension. An initial choice of nifedipine was associated with a lower requirement for subsequent doses of medication and no need for crossover to an alternative antihypertensive medication.<\/jats:p>","DOI":"10.1055\/a-2422-9768","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:25:51Z","timestamp":1730334351000},"page":"806-812","source":"Crossref","is-referenced-by-count":1,"title":["Short-Acting Oral Nifedipine versus Intravenous Labetalol for the Control of Severe Hypertension in the Postpartum Period: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-069X","authenticated-orcid":false,"given":"Whitney A.","family":"Booker","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Bejerano","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Frappaolo","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Stroke and Cerebrovascular Disease, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/01.AOG.0000151116.84113.56","article-title":"Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure","volume":"105","author":"J N Martin Jr","year":"2005","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref2","first-page":"409","article-title":"767 summary: emergent therapy for acute-onset, severe hypertension during pregnancy and the postpartum period","volume":"133","author":"ACOG Committee Opinion No","year":"2019","journal-title":"Obstet 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