{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T06:18:32Z","timestamp":1738217912358,"version":"3.34.0"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Eine 83-j\u00e4hrige Patientin wurde mit pectangin\u00f6sen Beschwerden, H\u00e4moglobinurie und Ikterus vorstellig. Nachdem sich die Labordiagnostik aufgrund einer H\u00e4molyse in allen Blutr\u00f6hrchen erschwert gestaltete, wurden diese gew\u00e4rmt ausgewertet.<\/jats:p><jats:p>Bei erniedrigtem Haptoglobin, erh\u00f6hter Laktatdehydrogenase und erh\u00f6htem indirekten Bilirubin stellten wir die Verdachtsdiagnose einer autoimmunh\u00e4molytischen An\u00e4mie mit K\u00e4lteantik\u00f6rpern, welche bei positivem Coombs-Test und Nachweis von C3d-beladenen Erythrozyten best\u00e4tigt werden konnte. Komplikativ zeigte sich ein NSTEMI Typ 2 im Rahmen der H\u00e4molyse sowie eine akute Nierensch\u00e4digung. Als Ausl\u00f6ser der AIHA wurde eine Proteus mirabilis-Bakteri\u00e4mie diagnostiziert.<\/jats:p><jats:p>Nach Behandlung des zugrundeliegenden Infekts und hochdosierter Therapie mit Prednisolon waren die H\u00e4molyseparameter r\u00fcckl\u00e4ufig und die Patientin konnte in die ambulante h\u00e4matologische Weiterbehandlung entlassen werden.<\/jats:p><jats:p>Die interdisziplin\u00e4re und die multiprofessionelle Zusammenarbeit mit dem Laborpersonal und der Transfusionsmedizin sind sowohl f\u00fcr eine z\u00fcgige Diagnosestellung als auch die weitere Therapie entscheidend. Bluttransfusionen sollten bei AIHA nur nach strenger Indikationsstellung erfolgen.<\/jats:p>","DOI":"10.1055\/a-2432-3518","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:30:26Z","timestamp":1738193426000},"page":"163-166","source":"Crossref","is-referenced-by-count":0,"title":["83-J\u00e4hrige mit Angina pectoris, H\u00e4moglobinurie und Ikterus"],"prefix":"10.1055","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3811-7818","authenticated-orcid":false,"given":"Franziska","family":"Dickmann","sequence":"additional","affiliation":[{"name":"St. Antonius-Hospital, Eschweiler, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Janssens","sequence":"additional","affiliation":[{"name":"St. Antonius-Hospital, Eschweiler, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/ajh.10062","article-title":"Autoimmune hemolytic anemia","volume":"69","author":"BC Gehrs","year":"2002","journal-title":"Am J Hematol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00063-022-00980-y","article-title":"H\u00e4molytische An\u00e4mien in der Notfall- und Intensivmedizin","volume":"118","author":"DA Eichenauer","year":"2023","journal-title":"Medizinische Klinik \u2013 Intensivmedizin und Notfallmedizin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1182\/asheducation-2018.1.382","article-title":"Autoimmune hemolytic anemia","volume":"2018","author":"A Hill","year":"2018","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100648","DOI":"10.1016\/j.blre.2019.100648","article-title":"Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting","volume":"41","author":"U Jager","year":"2020","journal-title":"Blood Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1056\/NEJMra2033982","article-title":"Autoimmune Hemolytic Anemias","volume":"385","author":"S Berentsen","year":"2021","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1080\/1744666X.2022.2089115","article-title":"Autoimmune hemolytic anemia: causes and consequences","volume":"18","author":"B Fattizzo","year":"2022","journal-title":"Expert Rev Clin Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.hoc.2021.11.001","article-title":"Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia","volume":"36","author":"MA Gertz","year":"2022","journal-title":"Hematol Oncol Clin North Am"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2432-3518.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:30:49Z","timestamp":1738193449000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2432-3518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":7,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,1,29]]},"published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2432-3518","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}