{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:21:36Z","timestamp":1742962896318,"version":"3.40.3"},"reference-count":5,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Vorstellung eines 55-j\u00e4hrigen, bis dahin gesunden Patienten erfolgte aufgrund eines Leistungsknicks und einer seit 3 Wochen bestehenden Gelbf\u00e4rbung der Haut. Zur St\u00e4rkung des Immunsystems hatte er seit 4 Monaten 7 verschiedene chinesische Kr\u00e4uter eingenommen. Klinisch fanden sich ein Ikterus, eine Druckdolenz im rechten Oberbauch sowie eine hepatitische Enzephalopathie (HE) Grad I.<\/jats:p><jats:p>Laborchemisch bestanden eine Koagulopathie sowie erh\u00f6hte Transaminasen- und Cholestase-Parameter, bei lediglich leicht erh\u00f6htem Ammoniakspiegel. Sonografisch konnten eine Fibrose oder Zirrhose sowie eine Perfusionsst\u00f6rung ausgeschlossen werden.<\/jats:p><jats:p>Aufgrund des zeitlichen Verlaufs und fehlender hepatischer Vorerkrankung wurde ein akutes Leberversagen (ALV), bedingt durch die Einnahme der chinesischen Kr\u00e4uter, diagnostiziert.<\/jats:p><jats:p>Bei ambivalentem Patientenwillen erfolgte die Zuweisung an ein Transplantationszentrum inklusive Listung verz\u00f6gert. Nach einer Lebertransplantation trat bei einem abdominalen Kompartmentsyndrom ein Graftversagen auf. W\u00e4hrend der High-risk-Re-Transplantation kam es zu einer Thrombusbildung im rechten Ventrikel \u2013 mit letalem Ausgang.<\/jats:p><jats:p>Die fr\u00fchzeitige Diagnosestellung eines ALV und Zuweisung an ein Transplantationszentrum (bei HE und INR \u2265 2) sind sehr wichtig.<\/jats:p>","DOI":"10.1055\/a-2433-1903","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:55:38Z","timestamp":1742000138000},"page":"359-362","source":"Crossref","is-referenced-by-count":0,"title":["Letaler Verlauf: Wenn Pflanzen auf die Leber schlagen"],"prefix":"10.1055","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2126-0898","authenticated-orcid":false,"given":"Lisa","family":"van der Lely","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich, Institut f\u00fcr Intensivmedizin, Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rea","family":"Andermatt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich, Institut f\u00fcr Intensivmedizin, Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Lienhardt","sequence":"additional","affiliation":[{"name":"Spital B\u00fclach, Interdisziplin\u00e4re Intensivsation, B\u00fclach, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"RT Stravitz","year":"2019","journal-title":"Lancet"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jhep.2016.12.003","article-title":"EASL Clinical Practice Guidelines on the management of acute (fulminant) liver failure","volume":"66","author":"J Wendon","year":"2017","journal-title":"J Hepatol"},{"issue":"20","key":"ref3","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.12998\/wjcc.v9.i20.5490","article-title":"Herb-induced liver injury: Systematic review and meta-analysis","volume":"9","author":"VR Ballotin","year":"2021","journal-title":"World J Clin Cases"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1665-2681(19)30796-3","article-title":"Traditional Chinese Medicine and herbal hepatotoxicity: A tabular compilation of reported cases","volume":"14","author":"R Teschke","year":"2015","journal-title":"Ann Hepatol"},{"issue":"07","key":"ref5","doi-asserted-by":"publisher","first-page":"e13752","DOI":"10.1111\/jfbc.13752","article-title":"Effects of medicine food Fructus Gardeniae on liver and kidney functions after oral administration to rats for 12 weeks","volume":"45","author":"C Li","year":"2021","journal-title":"J Food Biochem"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2433-1903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T21:05:48Z","timestamp":1742936748000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2433-1903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":5,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,3,14]]},"published-print":{"date-parts":[[2025,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2433-1903","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"type":"print","value":"0012-0472"},{"type":"electronic","value":"1439-4413"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}