{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T23:40:03Z","timestamp":1749253203146,"version":"3.41.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Background\u2003As the number of extremity amputations continues to rise, so does the demand for prosthetics. Emphasizing the importance of a nerve interface that effectively amplifies and transmits physiological signals through peripheral nerve surgery is crucial for achieving intuitive control. The regenerative peripheral nerve interface (RPNI) is recognized for its potential to provide this technical support. Through animal experiment, we aimed to confirm the actual occurrence of signal amplification.<\/jats:p><jats:p>\n               Methods\u2003Rats were divided into three experimental groups: control, common peroneal nerve transection, and RPNI. Nerve surgeries were performed for each group, and electromyography (EMG) and nerve conduction studies (NCS) were conducted at the initial surgery, as well as at 2, 4, and 8 weeks postoperatively.<\/jats:p><jats:p>\n               Results\u2003All implemented RPNIs exhibited viability and displayed adequate vascularity with the proper color. Clear differences in latency and amplitude were observed before and after 8 weeks of surgery in all groups (p\u2009&lt;\u20090.05). Notably, the RPNI group demonstrated a significantly increased amplitude compared with the control group after 8 weeks (p\u2009=\u20090.031). Latency increased in all groups 8 weeks after surgery. The RPNI group exhibited relatively clear signs of denervation with abnormal spontaneous activities (ASAs) during EMG.<\/jats:p><jats:p>\n               Conclusion\u2003This study is one of few preclinical studies that demonstrate the electrophysiological effects of RPNI and validate the neural signals. It serves as a foundational step for future research in human\u2013machine interaction and nerve interfaces.<\/jats:p>","DOI":"10.1055\/a-2434-4605","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T23:14:37Z","timestamp":1727997277000},"page":"478-488","source":"Crossref","is-referenced-by-count":0,"title":["Electrophysiological Signal Validation of Regenerative Peripheral Nerve Interface at Nerve Ending: A Preliminary Rat Model Experiment"],"prefix":"10.1055","volume":"41","author":[{"given":"Jeongmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsuk Peter","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsik","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-9704","authenticated-orcid":false,"given":"Joon Pio","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.apmr.2013.10.032","article-title":"Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, osteoarthritis, rheumatoid arthritis, limb loss, and back pain","volume":"95","author":"V Y Ma","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00005373-198302000-00012","article-title":"Neuroma formation following digital amputations","volume":"23","author":"G T Fisher","year":"1983","journal-title":"J Trauma"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1302\/0301-620X.96B1.31905","article-title":"A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: a prospective study of 51 patients","volume":"96-B","author":"R Br\u00e5nemark","year":"2014","journal-title":"Bone Joint J"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.0909-8836..t01-2-.x","article-title":"Biological factors contributing to failures of osseointegrated oral implants. 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